Expression and Regulation Profile of Mature MicroRNA in the Pig: Relevance to Xenotransplantation

Table 2

miRNAs in pig adipose tissue.

miRNA	Target	Function	Reference
miR-143	ERK5	It promotes adipocyte differentiation	[46–49]
miR-210		It promotes adipogenesis	[14, 50]
miR-27 family	INSR; IRS1–4; PDK1/2; CREB; S6K1	It inhibits adipogenesis	[14, 51]
miR-148a-3p		It is involved in differentiation of 3T3-L1 preadipocytes	[50]
let-7a-1-5p; let-7f-5p		They play potential housekeeping roles in adipocytes	[52]
miR-155-5p	C/EBP-b	It inhibits adipogenesis	[52–55]
miR-193b-3p; miR-365		They act as central regulators of brown fat differentiation and adipogenesis	[52]
miR-374b-5p	C/EBP-b	It is involved in the effect of maternal dietary protein on lipid metabolism	[52]
miR-18a-3p; miR-20-3p; miR-19b-1-5p; miR-181a-2-3p; miR-181b-2-3p		They are involved in development and production of proinflammatory B-cells and T-cells	[52, 56, 57]