Genetic Polymorphisms of IL1B, IL6, and TNFα in a Chinese Han Population with Pulmonary Tuberculosis
Table 2
Characteristics of the SNPs in our study.
Gene/SNPs
chromosome
Location on chromosome
Location in the gene
MA
MAF
MA
MAF
HWE
LTBI
HCS
LTBI
HCS
IL1B
rs1143634
2
113590390
Nonsynon_exon 5
A
0
A
0
0.99
0.94
rs16944
2
113594867
5′FLANKING
A
0.44
A
0.51
0.44
0.19
rs1143623
2
113595829
5′FLANKING
G
0.57
G
0.6
0.97
0.97
IL6
rs17147230
7
22762176
Intergenic
T
0.46
T
0.49
0.88
0.58
rs1800795
7
22766645
5′FLANKING
C
0.01
C
0.01
0.99
<0.0
rs2069837
7
22768027
intron2
G
0.19
G
0.22
0.2
0.98
TNFα
rs1799964
6
31542308
5′FLANKING
C
0.18
C
0.16
0.91
0.79
rs1800630
6
31542476
5′FLANKING
A
0.15
A
0.14
0.96
0.99
rs1799724
6
31542482
5′FLANKING
T
0.11
T
0.17
0.76
0.69
rs1800629
6
31543031
5′FLANKING
A
0.06
A
0.08
0.94
0.98
rs361525
6
31543101
5′FLANKING
A
0.03
A
0.03
0.92
0.08
SNP, single nucleotide polymorphism; LTBI, latent tuberculosis infection; HCS, healthy controls; MA, minor allele; MAF, minor allele frequency; HWE, Hardy Weinberg equilibrium. to HWE < 0.05, it was excluded from our study.
