Genetic Polymorphisms of IL1B, IL6, and TNFα in a Chinese Han Population with Pulmonary Tuberculosis
Table 4
Haplotypes of the IL1B, IL6 and TNFα genes and their distributions in the three groups.
Haplotype
PTB, (%)
LTBI, (%)
HCS, (%)
PTB VS. LTBI value
OR (95% CI)
LTBI VS. HCS P value
OR (95% CI)
IL1B
CGA
23.06 (0.1)
33.20 (0.1)
35.71 (0.1)
0.120
0.65 (0.37–1.12)
0.750
0.92 (0.56–1.51)
CGG
230.90 (0.6)
192.64 (0.5)
198.30 (0.5)
1.34 (1.01–1.76)
0.690
0.94 (0.72–1.25)
GGA
158.98 (0.4)
169.95 (0.4)
161.77 (0.4)
0.200
0.83 (0.63–1.10)
0.560
1.09 (0.82–1.44)
IL6
AA
221.06 (52.9)
200.16 (49.1)
3.91 (1.0)
0.701
1.06 (0.8–1.39)
0.390
1.13 (0.86–1.49)
AT
122.94 (29.4)
118.90 (29.7)
119.84 (29.4)
0.952
0.99 (0.73–1.34)
0.872
1.03 (0.76–1.39)
GT
64.06 (15.3)
66.10 (16.5)
82.16 (20.1)
0.656
0.92 (0.63–1.34)
0.197
0.79 (0.55–1.13)
TNFα
CCGAG
81.97 (0.2)
58.98 (0.2)
55.94 (0.1)
0.070
1.40 (0.97–2.03)
0.660
1.09 (0.74–1.62)
CTACG
28.95 (0.1)
24.00 (0.1)
30.97 (0.1)
0.600
1.16 (0.66–2.03)
0.380
0.78 (0.45–1.35)
CTGCG
246.05 (0.6)
240.48 (0.6)
250.94 (0.6)
0.670
0.94 (0.71–1.24)
0.720
0.95 (0.71–1.27)
TTGCG
46.98 (0.1)
64.52 (0.2)
59.06 (0.2)
0.66 (0.44–0.98)
0.500
1.14 (0.78–1.68)
Other
29.00 (2.4)
24.10 (2.0)
18.32 (1.5)
PTB, pulmonary tuberculosis; LTBI, latent tuberculosis infection; HCS, healthy controls; CI, confidence interval; OR, odds ratio; subjects which lowest frequency both in case and control less than 0.03; .
