Reviews of Interleukin-37: Functions, Receptors, and Roles in Diseases

Table 4

Protective effect and mechanisms of IL-37 in ischemia-reperfusion (I/R) injury.

Diseases	Model	Cell	Mechanism	Reference
Hepatic I/R injury	Mice	Hepatocytes and Kupffer cells	↓TNF-α ↓MIP-2 ↓ROS; ↑Bcl-2	[44]
Myocardial I/R injury	Mice	Cardiomyocytes and neutrophils	↓ROS ↓TLR-4↓NF-κB signaling ↓LIX ↓KC; ↑IL-10 ↑Bcl-2/Bax ratio	[49]
Renal I/R injury	Mice	Tubular epithelial cells	↓TNF-α ↓IL-6 ↓IL-1β	[50]

TLR: Toll-like receptor. NF-κB: nuclear factor kappa B. ROS: reactive oxygen species; ↑: upregulate. ↓: downregulate.