Reviews of Interleukin-37: Functions, Receptors, and Roles in Diseases

Table 6

Antitumor effects and mechanisms of IL-37 in cancers.

Cancer type	Cell lines	Model	Mechanism	References
Fibrosarcoma	MCA205	Mice	Unclear, may be related to IFN-γ, functional T cells, and B cells	[13]
Hepatocellular carcinoma	Hep3B and Hepa1-6	Mice	↑CD57+ NK cells	[21]
Non-small-cell lung cancer	H1299	Mice	Unclear, may inhibit tumor angiogenesis, VGEF, and CD34	[23]
Renal cell carcinoma	BEL-7402	No	↓STAT3 pathway ↓IL-6 ↓HIF-1α; ↓Bcl-2 ↓Cyclin D1	[24]
Cervical cancer	Hela and C33A	No	↓STAT3 pathway ↑TNF-α↑IL-1β	[25]
Oral squamous cell carcinoma	THP-1 and RAW264.7	No	↓IL-6 ↓TNF-α↓IL-1β	[76]

↑: upregulate. ↓: downregulate.