In Vitro Antifungal Susceptibility of Candida Species Isolated from Iranian Patients with Denture Stomatitis

Table 2

In vitro antifungal susceptibility of eight antifungal agents against 134 Candida spp. isolated from Candida-associated denture stomatitis.

Candida species/number of strains/antifungal drugs	MIC µg/mL
	MIC range	MIC50	MIC90	GM
All Candida species (134)
FLC	0.016–16	0.125	8	0.26
ITC	0.016–16	0.064	0.5	0.08
VRC	0.016–4	0.125	0.5	0.11
AMB	0.016–2	0.064	0.25	0.05
CAS	0.008–2	0.125	0.5	0.12
TRB	2–≥128	128	>128	65.00
POS	0.032–0.5	0.016	0.125	0.03
KET	0.016–4	0.125	1	0.15
C. albicans (84)
FLC	0.016–16	0.064	2	0.09
ITC	0.016–0.5	0.032	0.5	0.04
VRC	0.032–0.25	0.064	0.25	0.08
AMB	0.008–0.25	0.032	0.25	0.03
CAS	0.008–1	0.064	0.5	0.08
TRB	2–≥128	128	128	96.68
POS	0.032–0.5	0.016	0.032	0.01
KET	0.016–2	0.125	1	0.09
C. glabrata (23)
FLC	0.25–≥16	4	64	5.24
ITC	0.125–0.5	0.25	0.5	0.26
VRC	0.125–2	0.25	0.5	0.24
AMB	0.032–0.5	0.032	0.5	0.07
CAS	0.008–2	0.5	1	0.51
TRB	8–>128	16	64	19.77
POS	0.125–0.5	0.125	0.5	0.19
KET	0.064–1	0.125	0.5	0.14
C. tropicalis (16)
FLC	0.125–≥16	0.125	4	0.42
ITC	0.016–16	0.016	4	0.27
VRC	0.016–4	0.032	2	0.08
AMB	0.016–2	0.125	1	0.17
CAS	0.008–1	0.032	0.125	0.05
TRB	4–≥128	64	128	53.81
POS	0.016–0.25	0.032	0.25	0.05
KET	0.032–4	0.25	2	0.23
C. parapsilosis (11)
FLC	0.25–4	0.25	2	0.46
ITC	0.125–8	0.25	4	0.46
VRC	0.25–2	0.25	1	0.41
AMB	0.016–2	0.25	1	0.19
CAS	0.008–2	0.25	1	0.41
TRB	4–≥128	128	128	49.74
POS	0.032–0.125	0.032	0.125	0.05
KET	0.125–2	0.125	1	0.25

FLC, fluconazole; ITC, itraconazole; VRC, voriconazole; AMB, amphotericin B; CAS, caspofungin; TRB, terbinafine; POS, posaconazole; KET, ketoconazole; GM, geometric mean; MIC, minimum inhibition concentration; MIC50 and MIC90, concentration at which 50% and 90% of the strains were inhibited, respectively.