Term ID Term name Count Fold Enrichment catalogue Genes GO:0010951 negative regulation of endopeptidase activity 16 7.22 × 10−10 8.425 Biology Process KNG1, MUG2, MUG1, SERPINA10, PZP, C5, AHSG, AMBP, SERPINA3N, SERPINF2, SERPINA4, SERPINC1, ITIH4, HRG, ITIH2, SERPIND1 GO:0019373 epoxygenase P450 pathway 7 5.88 × 10−7 21.821 Biology Process CYP2C6V1, CYP2B3, CYP2J4, CYP2C23, CYP2C13, CYP2A1, CYP2A2 GO:0006953 acute-phase response 7 7.97 × 10−6 14.356 Biology Process KNG1, MUG1, CRP, ITIH4, SAA4, SERPINA1, AHSG GO:0007596 blood coagulation 8 2.08 × 10−5 9.446 Biology Process F13B, F12, SERPINA10, C9, F9, SERPIND1, CPB2, PLG GO:0055114 oxidation-reduction process 23 3.29 × 10−5 2.753 Biology Process ALDH8A1, CYP2B3, CYP2J4, HSD3B5, DECR2, RGD1304810, CYP2D3, EGLN1, KMO, P4HTM, VAT1, IYD, CYP2C6V1, TDO2, CYP3A23/3A1, HIF1AN, CYP4F4, CYP2C23, CYP2C13, SH3BGRL3, RDH16, CYP2A1, CYP2A2 GO:0007010 cytoskeleton organization 10 3.95 × 10−5 6.089 Biology Process CCL24, TNIK, CAP2, TUBB2A, SVIL, CAMSAP1, STRIP2, TUBB6, TUBA1A, TUBB4B GO:0051918 negative regulation of fibrinolysis 4 6.93 × 10−5 44.533 Biology Process SERPINF2, HRG, CPB2, PLG GO:0007017 microtubule-based process 6 1.68 × 10−4 11.405 Biology Process TUBB2A, TUBB5, TUBB6, TUBA1A, DCTN1, TUBB4B GO:0046470 phosphatidylcholine metabolic process 4 6.75 × 10−4 22.267 Biology Process APOA5, PON1, GPLD1, LIPC GO:0042730 fibrinolysis 4 8.35 × 10−4 20.782 Biology Process F12, HRG, CPB2, PLG GO:0031100 organ regeneration 7 0.00110 5.995 Biology Process APOA2, BAAT, ADH1, ALDOC, APOA5, PRPS2, AHSG GO:0006958 complement activation, classical pathway 5 0.00123 10.532 Biology Process C9, C5, CRP, C4BPB, C4BPA GO:0006954 inflammatory response 12 0.00158 3.149 Biology Process CCL24, KNG1, TLR10, SERPINA3N, TNFRSF10B, MUG1, CCL21, C5, HRH4, CCL9, SERPINA1, CXCR3 GO:0050996 positive regulation of lipid catabolic process 3 0.00236 38.967 Biology Process APOA2, APOA5, ANGPTL3 GO:0070328 triglyceride homeostasis 4 0.00431 11.990 Biology Process APOC4, APOA5, LIPC, ANGPTL3 GO:0007568 aging 11 0.00745 2.721 Biology Process ADRB3, CYP3A23/3A1, CRYAB, ENDOG, ALDOC, CRP, SPINK1, IGFBP1, ATP5G3, SREBF2, HTR2A GO:0071346 cellular response to interferon-gamma 5 0.00766 6.388 Biology Process CCL24, SERPINA3N, CCL21, CCL9, CFH GO:0008203 cholesterol metabolic process 5 0.00811 6.285 Biology Process APOA2, PON1, LIPC, ANGPTL3, SREBF2 GO:0042632 cholesterol homeostasis 5 0.00906 6.089 Biology Process CAV3, APOA2, APOA5, LIPC, ANGPTL3 GO:0042246 tissue regeneration 4 0.00996 8.907 Biology Process SERPINA10, APOA5, IGFBP1, PLG GO:0046330 positive regulation of JNK cascade 5 0.0112 5.730 Biology Process DIXDC1, CCL21, SERPINF2, MAP3K10, TPD52L1 GO:0050921 positive regulation of chemotaxis 3 0.0134 16.700 Biology Process CCL21, C5, CXCR3 GO:0006956 complement activation 3 0.0153 15.587 Biology Process C8A, C5, CFH GO:2000649 regulation of sodium ion transmembrane transporter activity 3 0.0153 15.587 Biology Process CAV3, SCN1B, SCN2B GO:0042573 retinoic acid metabolic process 3 0.0173 14.613 Biology Process ALDH8A1, ADH1, RDH16 GO:0009395 phospholipid catabolic process 3 0.0217 12.989 Biology Process APOA2, ENPP2, ANGPTL3 GO:0001666 response to hypoxia 9 0.0230 2.598 Biology Process CRYAB, ANG, CAMK2G, ALDOC, CRP, SERPINA1, EGLN1, PAK1, LIPC GO:0055117 regulation of cardiac muscle contraction 3 0.0241 12.305 Biology Process CAV3, P2RX4, CALM3 GO:0055090 acylglycerol homeostasis 2 0.0254 77.933 Biology Process APOA5, ANGPTL3 GO:0034370 triglyceride-rich lipoprotein particle remodeling 2 0.0254 77.933 Biology Process APOA2, APOA5 GO:0031116 positive regulation of microtubule polymerization 3 0.0265 11.690 Biology Process CAV3, MAP1B, DCTN1 GO:0032956 regulation of actin cytoskeleton organization 4 0.0287 5.995 Biology Process DIXDC1, HRG, PAK1, SH3BGRL3 GO:0048247 lymphocyte chemotaxis 3 0.0317 10.627 Biology Process CCL24, CCL21, CCL9 GO:0070098 chemokine-mediated signaling pathway 4 0.0363 5.469 Biology Process CCL24, CCL21, CCL9, CXCR3 GO:0045959 negative regulation of complement activation, classical pathway 2 0.0378 51.956 Biology Process C4BPB, C4BPA GO:0002542 Factor XII activation 2 0.0378 51.956 Biology Process KNG1, F12 GO:0009725 response to hormone 5 0.0381 3.936 Biology Process ANG, APOA5, LIPC, ANGPTL3, SREBF2 GO:0042311 vasodilation 3 0.0402 9.352 Biology Process KNG1, P2RX4, ALB GO:0006631 fatty acid metabolic process 4 0.0413 5.196 Biology Process BAAT, DECR2, LIPC, ANGPTL3 GO:0007399 nervous system development 7 0.0428 2.741 Biology Process PLXNA4, SCN2B, CAMK2G, KREMEN1, MAP1B, DPYSL3, NUMBL GO:0048675 axon extension 3 0.0431 8.992 Biology Process SEMA7A, MAP1B, POU4F3 GO:0072659 protein localization to plasma membrane 4 0.0485 4.871 Biology Process CAV3, TNIK, FGF13, CDH1 GO:0006935 chemotaxis 4 0.0485 4.871 Biology Process CCL24, ENPP2, C5, CXCR3 GO:0006810 transport 6 0.0489 3.017 Biology Process P2RX4, DYNC1LI1, AFM, LOC360919, ALB, LOC500473 GO:0072562 blood microparticle 22 1.84 × 10−18 14.631 Cellular Components KNG1, GC, C9, MUG1, APCS, C4BPA, PLG, AHSG, C8A, AMBP, APOA2, AFM, SERPINF2, ALB, HPX, APOA5, PON1, CFH, SERPINC1, ITIH4, HRG, ITIH2 GO:0005615 extracellular space 49 2.19 × 10−11 2.922 Cellular Components MUG2, MUG1, PZP, CRP, GPLD1, SPINK1, ANPEP, AZGP1, APOA2, ANG, SEMA7A, SERPINA4, APOA5, CFH, SERPINA1, SEMA3B, KNG1, F12, APCS, LOC360919, F9, C8A, AMBP, SERPINA3N, SERPINF2, SCGB2A2, GC, SERPINA10, ENPP2, C5, CCL9, AHSG, CCL24, ALB, CCL21, SERPINC1, ANGPTL3, C4BPB, DPYSL3, C4BPA, PLG, AFM, HPX, PON1, METRNL, SERPIND1, IGFBP1, LIPC, CPB2 GO:0034364 high-density lipoprotein particle 7 4.31 × 10−8 32.313 Cellular Components APOA2, APOC4, APOA5, PON1, GPLD1, SAA4, LIPC GO:0070062 extracellular exosome 66 6.06 × 10−8 1.957 Cellular Components ALDH8A1, CYP2J4, MUG1, TUBB2A, CRP, GPLD1, ANPEP, CKB, AZGP1, APOA2, DES, PACSIN3, ANG, SERPINA4, ITIH4, TUBB5, CFH, TUBB6, ITIH2, SEMA3B, SERPINA1, TUBA1A, KNG1, F12, TNIK, APCS, CRYAB, F9, METTL7A, VAT1, AMBP, C8A, RPS16, SERPINF2, BHMT, PRNP, SLC27A2, PRPS2, GC, C9, SERPINA10, ALDOC, C5, CDH1, KMO, AHSG, ALCAM, ALB, SERPINC1, DOPEY2, HRG, TUBB4B, COTL1, PLG, P2RX4, AFM, HPX, ARF3, PON1, CALM3, PAPPA2, METRNL, SERPIND1, SH3BGRL3, MYH14, CPB2 GO:0031090 organelle membrane 11 2.10 × 10−7 9.591 Cellular Components CYP2C6V1, CYP2B3, UGT2B37, UGT2B17, CYP3A23/3A1, CYP4F4, CYP2C23, CYP2D3, CYP2C13, CYP2A1, CYP2A2 GO:0030018 Z disc 9 1.24 × 10−4 6.037 Cellular Components CAV3, JPH2, DES, CRYAB, BAG3, PDLIM3, PAK1, HOMER1, FLNC GO:0014704 intercalated disc 6 4.60 × 10−4 9.232 Cellular Components CAV3, SCN1B, DES, ATP2A2, FGF13, PAK1 GO:0030426 growth cone 9 6.13 × 10−4 4.772 Cellular Components ANG, CRP, MAP1B, CALM3, DPYSL3, FGF13, MYH14, PAK1, HAP1 GO:0005874 microtubule 11 8.97 × 10−4 3.658 Cellular Components DYNC1LI1, TUBB2A, CAMSAP1, MAP1B, TUBB5, TUBB6, FGF13, TUBA1A, DCTN1, TUBB4B, GLYATL2 GO:0043034 costamere 4 0.00196 15.695 Cellular Components SVIL, SYNM, HOMER1, FLNC GO:0005576 extracellular region 19 0.00456 2.088 Cellular Components APCS, C9, CRP, NTN4, GPLD1, SAA4, C4BPB, FGF13, PTH2, C4BPA, PLG, LOC500473, CCL24, C8A, SERPINA3N, ALB, APOA5, HRG, LIPC GO:0005789 endoplasmic reticulum membrane 16 0.00504 2.258 Cellular Components CYP2B3, CDIPT, HSD3B5, CYP2D3, SREBF2, CYP2C6V1, UGT2B37, UGT2B17, CYP3A23/3A1, ATP2A2, CYP4F4, CYP2C23, CYP2C13, CYP2A1, CYP2A2, SLC27A2 GO:0030424 axon 12 0.00657 2.609 Cellular Components GC, ALCAM, P2RX4, CRYAB, ALDOC, MAP1B, FGF13, CDH1, MYH14, PAK1, HOMER1, HTR2A GO:0034361 very-low-density lipoprotein particle 3 0.0192 13.848 Cellular Components APOA2, APOC4, APOA5 GO:0043231 intracellular membrane-bounded organelle 16 0.0302 1.825 Cellular Components KNG1, CYP2B3, CAV3, CYP2J4, HSD3B5, GPLD1, PLG, SREBF2, AMBP, UGT2B17, CYP3A23/3A1, PON1, CYP2C23, UGT2A3, CYP2A1, SLC27A2 GO:0005856 cytoskeleton 8 0.0345 2.605 Cellular Components TNIK, DES, FILIP1, MAP1B, FLNC, COTL1, TPM2, HAP1 GO:0044216 other organism cell 2 0.0376 52.316 Cellular Components C4BPB, C4BPA GO:0033017 sarcoplasmic reticulum membrane 3 0.0457 8.719 Cellular Components JPH2, ATP2A2, CAMK2G GO:0004867 serine-type endopeptidase inhibitor activity 15 6.34 × 10−11 11.167 Molecular Function MUG2, PZP, MUG1, SERPINA10, SPINK1, AMBP, SERPINA3N, SERPINF2, SERPINA4, SERPINC1, ITIH4, HRG, ITIH2, SERPINA1, SERPIND1 GO:0070330 aromatase activity 9 2.65 × 10−8 18.039 Molecular Function CYP2C6V1, CYP2B3, CYP3A23/3A1, CYP4F4, CYP2C23, CYP2D3, CYP2C13, CYP2A1, CYP2A2 GO:0008392 arachidonic acid epoxygenase activity 8 1.97 × 10−7 18.393 Molecular Function CYP2C6V1, CYP2B3, CYP2J4, CYP2C23, CYP2D3, CYP2C13, CYP2A1, CYP2A2 GO:0008395 steroid hydroxylase activity 8 5.35 × 10−7 16.035 Molecular Function CYP2C6V1, CYP2B3, CYP2J4, CYP2C23, CYP2D3, CYP2C13, CYP2A1, CYP2A2 GO:0020037 heme binding 13 1.46 × 10−6 6.122 Molecular Function CYP2B3, CYP2J4, CYP2D3, AMBP, CYP2C6V1, TDO2, CYP3A23/3A1, CYP4F4, CYP2C23, HRG, CYP2C13, CYP2A1, CYP2A2 GO:0008092 cytoskeletal protein binding 8 1.07 × 10−5 10.423 Molecular Function DES, PACSIN3, CRYAB, ALDOC, PDLIM3, CDH1, FLNC, ABCG2 GO:0005506 iron ion binding 13 1.11 × 10−5 5.031 Molecular Function CYP2B3, CYP2J4, CYP2D3, EGLN1, P4HTM, CYP2C6V1, CYP3A23/3A1, HIF1AN, CYP4F4, CYP2C23, CYP2C13, CYP2A1, CYP2A2 GO:0004866 endopeptidase inhibitor activity 5 5.40 × 10−4 13.028 Molecular Function MUG2, MUG1, C5, SERPINA1, AHSG GO:0017080 sodium channel regulator activity 5 6.95 × 10−4 12.214 Molecular Function CAV3, SCN1B, SCN2B, GPLD1, FGF13 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 5 8.78 × 10−4 11.495 Molecular Function CYP2B3, CYP2J4, CYP3A23/3A1, CYP2D3, CYP2A1 GO:0005200 structural constituent of cytoskeleton 6 0.00223 6.514 Molecular Function TUBB2A, TUBB5, TUBB6, SYNM, TUBA1A, TUBB4B GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors 4 0.00262 14.213 Molecular Function HIF1AN, RGD1304810, EGLN1, P4HTM GO:0008201 heparin binding 8 0.00268 4.283 Molecular Function SERPINA10, ANG, APOA5, SERPINC1, CFH, HRG, SERPIND1, LIPC GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 5 0.00297 8.316 Molecular Function CYP2C6V1, CYP2B3, CYP2C23, EGLN1, CYP2C13 GO:0005102 receptor binding 12 0.00666 2.598 Molecular Function KNG1, HAO1, P2RX4, BAAT, ANG, LRRC4B, DECR2, HRG, HOMER1, SLC27A2, HAP1, PLG GO:0004497 monooxygenase activity 5 0.00944 6.013 Molecular Function CYP2C6V1, CYP2B3, CYP2C23, CYP2D3, CYP2C13 GO:0004622 lysophospholipase activity 3 0.01328 16.751 Molecular Function ENPP2, LIPC, GDPD1 GO:0042803 protein homodimerization activity 19 0.01474 1.845 Molecular Function RBPMS2, CRYAB, GIMAP7, CAMK2G, CRP, NR4A1, TPD52L1, ABCG2, AMBP, ADRB3, APOA2, HIF1AN, ANG, SERPINF2, ADH1, TENM3, PON1, RDH16, PRPS2 GO:0005543 phospholipid binding 5 0.0198 4.825 Molecular Function APOA2, APOA5, MAP1B, PON1, SYTL3 GO:0044325 ion channel binding 6 0.0233 3.693 Molecular Function CAV3, CALM3, FGF13, PRNP, HOMER1, HAP1 GO:0048020 CCR chemokine receptor binding 3 0.0239 12.342 Molecular Function CCL24, CCL21, CCL9 GO:0043395 heparan sulfate proteoglycan binding 3 0.0289 11.167 Molecular Function CFH, HRG, LIPC GO:0030215 semaphorin receptor binding 3 0.0289 11.167 Molecular Function SEMA7A, SEMA3B, SH3BGRL3 GO:0005509 calcium ion binding 16 0.0330 1.797 Molecular Function MATN2, F12, APCS, CALR4, TBC1D9, ENPP2, CRP, DECR2, F9, CDH1, P4HTM, ATP2A2, PON1, ITIH4, CALM3, SYTL3 GO:0008307 structural constituent of muscle 3 0.0371 9.771 Molecular Function PDLIM3, SYNM, TPM2 GO:0003779 actin binding 8 0.0406 2.511 Molecular Function GC, DIXDC1, CAP2, ANG, DIAPH3, MAP1B, COTL1, TPM2 GO:0015020 glucuronosyltransferase activity 3 0.0460 8.685 Molecular Function UGT2B37, UGT2B17, UGT2A3 GO:0005507 copper ion binding 4 0.0463 4.963 Molecular Function P2RX4, ANG, PRNP, ATP7B GO:0005515 protein binding 29 0.0484 1.427 Molecular Function CAV3, GC, SCN1B, ALDOC, CRP, CDH1, RHOV, CKB, A1CF, TUBB5, SERPINC1, SERPINA1, PAK1, TUBA1A, HAP1, TUBB4B, SCN2B, CRYAB, MAP1B, HRK, NR4A1, HOMER1, NUMBL, P2RX4, ATP2A2, CALM3, SLC27A2, PRPS2, HTR2A
