Research Article

A Possible Mechanism: Vildagliptin Prevents Aortic Dysfunction through Paraoxonase and Angiopoietin-Like 3

Table 3

The enriched Kegg pathway with differentially expressed genes .

Pathway IDPathway nameCount-valueFold EnrichmentGenes

rno04610Complement and coagulation cascades167.92 × 10−1414.904KNG1, F12, C9, C5, F9, C4BPB, C4BPA, PLG, F13B, C8A, SERPINF2, CFH, SERPINC1, SERPINA1, SERPIND1, CPB2
rno00830Retinol metabolism123.00 × 10−89.697CYP2C6V1, CYP2B3, UGT2B37, UGT2B17, CYP3A23/3A1, ADH1, CYP2C23, CYP2C13, UGT2A3, CYP2A1, RDH16, CYP2A2
rno00140Steroid hormone biosynthesis102.63 × 10−68.280CYP2C6V1, CYP2B3, UGT2B37, UGT2B17, CYP3A23/3A1, HSD3B5, CYP2C23, CYP2D3, CYP2C13, UGT2A3
rno05204Chemical carcinogenesis95.47 × 10−56.633CYP2C6V1, CYP2B3, UGT2B37, UGT2B17, CYP3A23/3A1, ADH1, CYP2C23, CYP2C13, UGT2A3
rno00591Linoleic acid metabolism53.01 × 10−38.179CYP2C6V1, CYP2J4, CYP3A23/3A1, CYP2C23, CYP2C13
rno04750Inflammatory mediator regulation of TRP channels76.98 × 10−34.082CYP2C6V1, CYP2J4, CAMK2G, CYP2C23, CALM3, CYP2C13, HTR2A
rno04540Gap junction69.57 × 10−34.573TUBB2A, TUBB5, TUBB6, TUBA1A, TUBB4B, HTR2A
rno05020Prion diseases41.14 × 10−28.384C8A, C9, C5, PRNP
rno01100Metabolic pathways301.17 × 10−21.556CYP2B3, CYP2J4, PGS1, CDIPT, TUSC3, ALDOC, HSD3B5, KMO, ANPEP, ATP5G3, CKB, TDO2, ADH1, CYP2C13, UGT2A3, CYP2C6V1, MAN2A2, HAO1, UGT2B37, UGT2B17, BAAT, CYP3A23/3A1, BHMT, PON1, CYP2C23, LIPC, RDH16, CYP2A1, CYP2A2, PRPS2
rno00590Arachidonic acid metabolism53.16 × 10−24.140CYP2C6V1, CYP2B3, CYP2J4, CYP2C23, CYP2C13
rno04726Serotonergic synapse63.63 × 10−23.245CYP2C6V1, CYP2J4, CYP2C23, CYP2D3, CYP2C13, HTR2A
rno04360Axon guidance64.08 × 10−23.144PLXNA4, SEMA7A, NTN4, SEMA3B, PAK1, UNC5C