Linezolid Inhibited Synthesis of ATP in Mitochondria: Based on GC-MS Metabolomics and HPLC Method

Table 3

The blood metabolic changes in control-group (1), low-group (2), and high- group (3) after administration of linezolid with two different dosages.

No	VIP		Control-group	Low-group	High-group	1v2	1v3
		Compound	Mean±SD	Mean±SD	Mean±SD	P	P
1	3.01	Trimethyl phosphate	5±2.3	3.3±0.2	1.7±0.9	0.189	0.007
2	2.87	Urea	3.5±0.3	4.9±2.7	2.4±1.8	0.338	0.243
3	2.62	carbonate	3.2±1.8	5.5±4.3	5.1±1.2	0.368	0.244
4	1.95	Octadecanoic acid	2.7±0.9	1.8±0.2	2.3±0.4	0.013	0.256
5	1.82	d-Mannose	0.2±0	1.3±1. 9	0.1±0	0.496	0.035
6	1.73	d-Glucose	9.4±0.8	10.7±0.8	10.7±2.7	0.01	0.248
7	1.67	Cholest-5-ene	2.1±1	1.1±0.7	0.9±1.1	0.046	0.046
8	1.65	Hexadecanoic acid	2.5±0.4	2.3±0.5	1.8±0.2	0.378	0.001
9	1.51	l-Methionine	3.4±0.4	2.9±0.2	3.5±0.7	0.005	0.783
10	1.24	Butanoic acid	1.9±1.7	1.1±1.1	0.9±0.7	0.49	0.197
11	1.08	α-Linolenic acid	1.7±0.5	1.5±0.8	1.1±0.2	0.586	0.011
12	1.08	Arabinofuranose	0.6±0.1	0.6±0.1	0.4±0.1	0.076	0
13	1.06	Eicosapentaenoic acid	1.6±0.4	1.2±0.2	1.2±0.3	0.039	0.028
14	1.05	9,12-Octadecadienoic acid	1±0.2	0.6±0.2	0.6±0.3	0.002	0.009
15	1.05	Docosahexaenoic acid	1.5±0.2	1.4±0.3	1.2±0.1	0.487	0.002
16	1.00	Retinoic acid, methyl ester	1.9±0.7	1.5±0.2	1.5±0.4	0.126	0.13