Polymorphisms of TNF-α -308 G/A and IL-8 -251 T/A Genes Associated with Urothelial Carcinoma: A Case-Control Study
Table 1
Sociodemographic characteristics of 287 urothelial carcinoma cases and 574 matched noncancer controls, stratified by TNF-α and IL-8 genotypes.
Variable
TNF-α
IL-8
GG/GA
AA
p value
TT
TA/AA
p value
Age (years)
62.82 ± 13.56
59.18 ± 9.45
0.38
60.83 ± 13.55
65.59 ± 12.99
<0.0001
Gender
Male
591 (69.53)
10 (90.91)
0.19
357 (69.89)
244 (69.71)
0.96
Female
259 (30.47)
1 (9.09)
154 (30.14)
106 (30.29)
Educational level
Illiterate or elementary school
229 (27.00)
1 (9.09)
0.41
124 (24.31)
106 (30.37)
0.05
Junior or senior high school
304 (35.85)
5 (45.45)
181 (35.49)
128 (36.68)
College or university
315 (37.15)
5 (45.45)
205 (40.20)
115 (32.95)
Cigarette smoking
No
526 (61.88)
5 (45.45)
0.35
329 (64.38)
202 (57.71)
0.05
Yes
324 (38.12)
6 (54.55)
182 (35.62)
148 (42.29)
Environmental tobacco exposure
No
411 (51.31)
6 (54.55)
0.65
250 (51.98)
167 (50.45)
0.10
Yes
290 (36.20)
5 (45.45)
182 (37.84)
113 (34.14)
Alcohol consumption
No
497 (58.47)
5 (45.45)
0.68
297 (58.12)
205 (58.57)
0.11
Yes
167 (19.65)
3 (27.27)
111 (21.72)
59 (16.86)
Occasional
186 (21.88)
3 (27.27)
103 (20.16)
86 (24.57)
Educational level and environmental tobacco smoke were unavailable for two and 149 of the TNF-α GG/GA genotypes, respectively. Educational level and environmental tobacco smoke were unavailable for one and 79 of the IL-8 TT genotypes, respectively. Educational level and environmental tobacco smoke were unavailable for one and 70 of the IL-8 TA/AA genotypes, respectively.
