Polymorphisms of TNF-α -308 G/A and IL-8 -251 T/A Genes Associated with Urothelial Carcinoma: A Case-Control Study

Table 2

Dose-response relationship between cigarette smoking profiles and the odds ratio (OR) for urothelial carcinoma (UC).

	UC cases	Controls	Age/sex-adjusted OR (95% CI)	Multivariate-adjusted OR (95% CI)
Cigarette smoking (packs/day)
0	152	379	1.00	1.00
0~1	108	169	1.69 (1.10~2.61)	1.90 (1.19~3.03)
>1	27	26	2.39 (1.62~3.54)	2.33 (1.52~3.55)
Cigarette smoking (years)
0	153	379	1.00	1.00
0~31	49	101	1.46 (0.93~2.27)	1.49 (0.92~2.39)
>31	85	94	2.59 (1.74~3.86)	2.74 (1.77~4.24)
Cigarette smoking (pack years)
0	153	379	1.00	1.00
0~18	35	81	1.19 (0.73~1.94)	1.30 (0.78~2.19)
>18	99	114	2.62 (1.80~3.81)	2.64 (1.75~3.99)

Multivariate ORs were adjusted for age, gender, educational level, and alcohol consumption. < 0.05. CI: confidence interval.