BioMed Research International

Research Article

Polymorphisms of TNF-α -308 G/A and IL-8 -251 T/A Genes Associated with Urothelial Carcinoma: A Case-Control Study

Table 3

Adjusted odds ratios (ORs) of urothelial carcinoma risk by cumulative cigarette exposure, the tumor necrosis factor (TNF)-α -308 A/A genotype, and the interleukin (IL)-8 -251 T/T genotype.
Risk factorsAge/sex-adjusted OR (95% CI)Multivariate-adjusted OR (95% CI)
None1.001.00
Any one risk factor1.47 (0.99~2.19)1.55 (1.03~2.35)
Any two risk factors2.69 (1.63~4.43)2.89 (1.70~4.93)
All three risk factors3.61 (2.15~6.07)3.77 (2.16~6.56)
  < 0.0001 < 0.0001
The three risk factors were cumulative cigarette exposure,the TNF-α -308 A/A genotype, and the IL-8 -251 T/T genotype. Multivariate ORs were adjusted for age, gender, educational level, and alcohol consumption. < 0.05. CI: confidence interval.