Cytotoxic and Apoptotic Effects of Govaniadine Isolated from Corydalis govaniana Wall. Roots on Human Breast Cancer (MCF-7) Cells

Figure 9

DNA fragmentation analysis. Gel electrophoresis was carried out with DNA extracted from MCF-7 cells, after treatment with govaniadine. Lane 1: 100 bp size marker, Lane 2: control (0.1% DMSO), lane 3: 60 μM thymoquinone (positive control for fragmentation analysis) for 48 h, lane 4: 60 μM thymoquinone for 72 h, lane 5: 4 μM govaniadine for 48 h, lane 6: 8 μM govaniadine for 48 h, lane 7: 16 μM govaniadine for 48 h, lane 8: 4 μM govaniadine for 72 h, lane 9: 8 μM govaniadine for 72 h, lane 10: 16 μM govaniadine for 72 h.