Deletion of NAD(P)H Oxidase 2 Prevents Angiotensin II-Induced Skeletal Muscle Atrophy

Figure 1

Deletion of Nox2 prevents angiotensin II- (AII-) induced skeletal muscle atrophy. (a) Body and lower limbs skeletal muscle weights (Quadriceps (b), gastrocnemius (c), soleus (d), and total muscle (e)) from WT + V, KO + V, WT + AII, and KO + AII mice after 4 weeks ( = 6–8 for each group). Representative high-power photomicrographs of skeletal muscle tissue sections stained with hematoxylin-eosin (HE) from 4 groups of mice (f) and summary data of myocyte cross-sectional area (g) ( for each group). Scale bar, 100 μm. Data are expressed as means ± SEM. versus WT + V. versus WT + AII. WT, wild type; V, vehicle; KO, knockout.

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