Deletion of NAD(P)H Oxidase 2 Prevents Angiotensin II-Induced Skeletal Muscle Atrophy

Figure 2

Deletion of Nox2 regulates the balance between protein synthesis and degradation. Representative Western blot and the summary data of quantitative analysis of protein expressions of p-Akt (Ser473 (a)) and p-p70S6K (Thr389 (b)) and summary data of gene expressions of MuRF-1 (c) and atrogin-1 (d) in the skeletal muscle tissue obtained from WT + V, KO + V, WT + AII, and KO + AII mice ( for each group). Data are expressed as means ± SEM. versus WT + V. versus WT + AII. p-p70S6K, phosphorylation of p70 ribosomal S6 kinase; MuRF-1, Muscle RING Finger-1; atrogin-1, muscle atrophy F-box.

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