Homocysteine-Enhanced Proteolytic and Fibrinolytic Processes in Thin Intraluminal Thrombus and Adjacent Wall of Abdominal Aortic Aneurysm: Study In Vitro

Table 3

Correlations between parameters measured within tissue sections incubated in the absence of DL-homocysteine (DL-Hcy) (control) and the same parameters measured within thin and thick intraluminal thrombus (ILT) and adjacent walls of abdominal aortic aneurysm (AAA) sections after incubation with different concentrations of DL-Hcy.

		AAA wall parts adjacent to ILT				Intraluminal thrombus
		Site A		Site B		Site A1		Site B1
Parameter	Correlation	r	p	r	p	r	p	r	p
MMP-2	control vs 100 mol/L Hcy
	control vs 500 mol/L Hcy
MMP-9	control vs 100 mol/L Hcy
	control vs 500 mol/L Hcy
TF	control vs 100 mol/L Hcy
	control vs 500 mol/L Hcy
t-PA	control vs 100 mol/L Hcy
	control vs 500 mol/L Hcy
Plasminogen	control vs 100 mol/L Hcy
	control vs 500 mol/L Hcy
PAI-1	control vs 100 mol/L Hcy
	control vs 500 mol/L Hcy

r, p, Pearson's correlation coefficient and p-value; MMP-2,9, matrix metalloproteinase 2 or 9; TF, tissue factor; t-PA, tissue plasminogen activator; and PAI-1, plasminogen activator inhibitor-1. Site A = wall adjacent to thick ILT; site B = wall adjacent to thin ILT; site A1 = thick ILT; site B1 = thin ILT. Measurement units are given in Figure 1. Underlined values show significant correlations.