CD30 Is Highly Expressed in Chronic Obstructive Pulmonary Disease and Induces the Pulmonary Vascular Remodeling

Figure 4

CD30 decreased cell viability and cell migration in HPAEC and HPASMC cells. (a) Hypoxia induced the HIF-a expression in HPAEC and HPASMC cell lines. The proteins levels were detected by Western blotting. GAPDH as the internal control. (b) Cell viability was detected in HPAEC and HPASMC cell lines. CTR: control cells. Hypoxia: cells were cultured under anoxic conditions (oxygen concentration: % O2) for 24 h. Hypoxia-group cells were treated by 20 ng, 60 ng, and 100 ng of CD30, respectively, for 24 h. compared with control group cells, ; and compared with hypoxia-group cells, and , respectively. ((c) and (d)) Cell migration viability was detected by transwell assays in HPAEC and HPASMC cell lines. compared with control group cells, .   compared with hypoxia-group cells, . compared with hypoxia-group cells, .

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