Effect of Riociguat and Sildenafil on Right Heart Remodeling and Function in Pressure Overload Induced Model of Pulmonary Arterial Banding

Figure 1

Effect of sildenafil and riociguat on RV function in pressure overload model. Hemodynamic and MRI assessment on pulmonary artery banding (PAB) mice treated with sildenafil and riociguat. (a) Right ventricular systolic pressure (RVSPsys, mmHg). (b) Systemic blood pressure (SPBsys, mmHg). (c) Ratio of right ventricular (RV) weight to body weight (RV/BW, mg/g). (d) Ratio of RV weight to LV + septum weight (RV/LV + S, mg/mg). (e) Right ventricular end diastolic volume (RVED, μl). (f) Right ventricular end systolic volume (RVES, μl). (g) Right ventricular stroke volume (μl). (h) Right ventricular ejection fraction (%). Values are means ± SD. , , , , and mice per group.

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