Effect of Riociguat and Sildenafil on Right Heart Remodeling and Function in Pressure Overload Induced Model of Pulmonary Arterial Banding
Effects of sildenafil and riociguat and on RV cardiomyocyte size and collagen content after PAB. (a, b) Representative pictures and quantification of cardiomyocyte cross-sectional area based on a cell plasma membrane staining with wheat germ agglutinin- (WGA-) FITC (mean ± SD, 5 mice per group, ). Scale bar 100 μm. (c, d) Representative images and assessment of RV collagen area (%), representing reduced collagen content in riociguat-treated samples (mean ± SD, 5 mice per group, , ). Scale bar 100 μm.
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