BioMed Research International / 2018 / Article / Fig 3

Research Article

Effect of Riociguat and Sildenafil on Right Heart Remodeling and Function in Pressure Overload Induced Model of Pulmonary Arterial Banding

Figure 3

Effects of sildenafil and riociguat on collagen production and phospho-Smad2/3 expression in TGF-beta stimulated RV cardiac fibroblasts. (a) Effects of the sildenafil and riociguat on collagen secretion in RV cardiac fibroblasts (mean ± SD, independent experiments, , ). (b) Western Blot images p-SMAD2/SMAD2, p-SMAD3/SMAD3, and Pan-actin from the proteins isolated from RV cardiac fibroblasts. The blot is representative of the three independent runs/experiments.

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