Saccharomyces cerevisiae-Derived Mannan Does Not Alter Immune Responses to Aspergillus Allergens

Figure 5

Transgenic mice expressing human MN receptor develop allergic airways disease. Airway inflammation in response to allergen sensitization and challenge in transgenic mice was equivalent with and without MN (a). However, MN treatment of these mice led to an influx of granulocytes and a reduction in lymphocytes (b). Goblet cells in the airways appeared unaffected by MN treatment (c), while expression of Muc5ac and Muc5b genes was similar between treated and untreated allergic mice (d). Data are represented as the mean and standard deviation in -5 mice per group. Dashed-dotted lines in (d) represent expression in naïve controls. Data in each group were analyzed by Mann–Whitney test, and denotes and denotes .

(a)

(b)

(c)

(d)