CD4⁺CD45RA⁻FOXP3^low Regulatory T Cells as Potential Biomarkers of Disease Activity in Systemic Lupus Erythematosus Brazilian Patients

Figure 2

FOXP3⁺ Tregs subset phenotyping in patients with systemic lupus erythematosus (SLE) and healthy donors. (a) Gating strategy for Treg cells characterization in PBMCs: lymphocytes gate (1); TCD4⁺ lymphocytes (2); CD4⁺CD45RA⁺ (naïve Tregs) (3); CD4⁺CD45RA^- (eTregs) (4); CD4⁺CD45RA^- (Foxp3⁺nonTreg) (5). (b) naïveTreg, eTreg, and Foxp3⁺nontreg in TCD4⁺ cells. p < 0.05; p≤0.002; p<0.0001.

(a)

(b)