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Probiotic strain | Subjects | Dose and duration of study | Effects (P<0.05) | Ref |
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Lactobacillus plantarum CGMCC, Lactobacillus acidophilus-11 and Bifidobacterium longum-88 | (i) Colorectal cancer patients (ii) 150 patients (1;1 ratio of probiotic and placebo group) | (i) Lactobacillus plantarum CGMCC no.1258;1011(CFU)/g (ii) Lactobacillus acidophilus;1011CFU/g, (iii) Bifidobacterium longum-881010 (CFU/g) (iv) The patients administrated with probiotic 6 days preoperatively and 10 days postoperative. | Probiotics decreased the serum zonulin concentration, duration of postoperative pyrexia, duration of antibiotic therapy, and rate of postoperative infectious complications as well as inhibited the p38 mitogen-activated protein kinase signalling pathway. | [54] |
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Lactobacillus rhamnosus LC705 and Propionibacterium freudenreichii subsp. shermanii strains | (i) Aflatoxin-induced liver cancer (ii) 90 male students with high aflatoxin level in urine | 5 weeks, (1:1, wt: wt) at a dose of 2–5×1010 colony-forming units/day | 61.5% reduction of a liver cancer biomarker which leads to reduced urinary excretion of aflatoxin B1-N7guanine (AFB-N7-guanine) | [55] |
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Lactobacillus casei Shirota(LcS) | (i) Breast cancer (ii) 968 breast cancer patients (306 probiotic group; 662 control) aged 40 to 55. | Frequent consumption of Yakult containing Lactobacillus casei Shirota and isoflavones from soy product for 2 years | Regular consumption of LcS and isoflavones since adolescence was inversely associated with the incidence of breast cancer in Japanese women. | [56] |
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Lactobacillus acidophilus L1 | (i) Bladder cancer (ii) A total of 180 cases (mean age: 67 years, SD 10) and 445 population-based controls | 200 g of yoghurt containing L. acidophilus L1 for 10 weeks | Habitual intake of lactic acid bacteria reduces the risk of bladder cancer. | [57] |
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Lactobacillus casei Shirota (LcS) | (i) Cervical cancer (ii) 54 women with an HPV-positive intra epithelial lesion | Daily administration of (Yakult) containing LcS for 6 months. | 60 % reduction in human papilloma virus (HPV) associated infection and cervical cancer precursors. | [8] |
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