Urinary Metabolomics Study of Patients with Gout Using Gas Chromatography-Mass Spectrometry
Table 2
Significantly changed urinary metabolites in patients with gout.
Metabolite
aVIP
bP
Trend
Metabolic pathway
Ethanolamine
1.82
2.91E-03
↓
Glycerophospholipid metabolism
Phenylethanolamine
1.67
9.76E-03
↓
Glycerophospholipid metabolism
Glycolate
2.3
1.41E-04
↓
Glycerophospholipid metabolism
Glycerol
1.74
4.35E-03
↓
Glycerolipid metabolism
Galacturonate
1.32
2.52E-02
↑
Unknowm
Stearate
1.34
2.34E-02
↓
Unsaturated fattyacids metabolism
Succinate
1.6
1.20E-02
↓
TCA cycle
Fumarate
1.47
1.23E-02
↓
TCA cycle
Isoleucine
1.75
6.29E-03
↓
Valine, leucine and isoleucine metabolism
Serine
1.78
4.63E-03
↓
Glycine, serine and threonine metabolism
Glycine
2.49
1.08E-04
↓
Glycine, serine and threonine metabolism
Threonine
1.32
3.57E-02
↓
Glycine, serine and threonine metabolism
Aspartate
2.53
5.26E-05
↓
Alanine,aspartate and glutamate metabolism
Pyroglutamate
1.31
0.027421134
↓
Alanine, aspartate and glutamate metabolism
Phenylalanine
1.44
2.10E-02
↓
Phenylalanine metabolism
Propylene glycol
2.09
1.22E-03
↓
Propanoate metabolism
5-Hydroxy-l-tryptophan
1.39
1.81E-02
↑
Tryptophan metabolism
L-Tryptophan
1.45
1.37E-02
↓
Tryptophan metabolism
5-Hydroxyindole-3-acetate
1.58
9.73E-03
↓
Tryptophan metabolism
Beta-lactate
2
1.24E-03
↓
Glycolysis metabolism
Threonate
1.26
3.35E-02
↑
Ascorbate and aldarate metabolism
D-lyxose
1.33
4.48E-02
↓
Pentose and glucuronate interconversions
Ribitol
1.76
2.48E-03
↓
Pentose and glucuronate interconversions
Sorbitol
1.95
1.74E-03
↓
Fructose and mannose metabolism
D-allose
1.34
3.42E-02
↓
Fructose and mannose metabolism
Gluconate
2.34
3.37E-05
↑
Pentose phosphate pathway
Uracil
1.76
4.67E-03
↓
Pyrimidine metabolism
Urate
1.39
1.81E-02
↑
Nucleotide metabolism
Creatinine
1.61
5.89E-03
↓
Arginine and proline metabolism
Isoxanthopterin
2.75
2.40E-07
↑
Unknown
“aVIP” value was obtained from OPLS-DA with a threshold of 1.0; “bP”values were calculated from Student t-test; “↓” means the level was decreased in the urine of gout patients, and “↑” means the level was increased in gout patients; “Unknown” means the metabolic pathway of corresponding metabolite was nonexistent in the KEGG database.
