A Review on Adducin from Functional to Pathological Mechanisms: Future Direction in Cancer

Figure 1

The structural proteins in the spectrin-based membrane skeleton at the cytoplasmic surface of plasma membrane. Spectrin is a rod-shaped protein that binds with actin filaments at each end. Spectrin and actin associate with accessory proteins (ankyrin and protein 4.1) at the junctional complex and connect with tropomyosin and tropomodulin to form a polygonal structure in the membrane cytoskeleton. Glycophorin C and Band 3 are the integral membrane proteins involved in the spectrin-based skeleton conferring the membrane with strength and deformability.