Amelioration of Lipopolysaccharide-Induced Acute Lung Injury in Rats by Na-H Exchanger-1 Inhibitor Amiloride Is Associated with Reversal of ERK Mitogen-Activated Protein Kinase

Figure 2

Morphologic changes and acute lung injury scores of lungs. (C) C group: no lung injury was observed. (A) A group: no lung injury was observed. (L) L group: the inflammatory process with marked infiltration of leukocytes into interstitial and alveolar spaces, edema, alveolar distortion, and thickening of alveolar wall. (AL) AL group: the damage was less pronounced. Hematoxylin-eosin-safranin stain was applied to the sections. Original magnification, 200X. (S) Acute lung injury scores of groups. Values are mean ± SD (n=8 per group). ^∗p<0.05 versus L group.