Cinnamaldehyde Improves Lifespan and Healthspan in Drosophila melanogaster Models for Alzheimer’s Disease

Figure 1

The effect of cinnamaldehyde on the lifespan of Alzheimer's disease (AD) flies overexpressing MAPT (Tau). (a, b) 16 mM cinnamaldehyde (CM) significantly increased the lifespan of AD flies overexpressing the Tau protein in males by 2% and females by 17.5% (P=0.0054, male control n = 112, male CM n = 109, P < 0.0001, female control n = 118, and female CM n = 118). (c, d) 80 mM cinnamaldehyde significantly increased the lifespan of AD flies overexpressing the Tau protein in males by 11.7% and in females by 20.7% (male control n = 112, male CM n = 117, female control n = 118, and female CM n = 115, P < 0.0001). (e, f) 400 mM cinnamaldehyde was toxic to AD flies overexpressing the Tau protein in both males and females (male control n = 112, male CM n = 113, female control n = 118, and female CM n = 118, P < 0.0001).

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