Identification of Hub Genes and Key Pathways Associated with Two Subtypes of Diffuse Large B-Cell Lymphoma Based on Gene Expression Profiling via Integrated Bioinformatics

Figure 4

DEG PPI network complex and modular analysis. (a) Using the STRING online database, 28 of 87 DEGs (21 ABC-upregulated genes in green, 7 downregulated genes in purple; hub genes are indicated with round shapes) were filtered into the DEG PPI network complex. (b) According to the above method, other networks with no more than 50 interactors were also analyzed. The hub genes are shown in orange, and the other genes linked to the DEGs are shown in blue. The highlighted circled areas are the most significant modules. (c) This module consists of 34 nodes and 222 edges (ABC-upregulated genes in green; downregulated gene in red; hub genes are indicated with diamond shapes and DEGs are indicated with rectangle shapes; and other linked genes are in orange and with round shapes), which are mainly associated with the regulation of biological processes, cellular components, and protein binding.

(a)

(b)

(c)