Identification of Hub Genes and Key Pathways Associated with Two Subtypes of Diffuse Large B-Cell Lymphoma Based on Gene Expression Profiling via Integrated Bioinformatics

Table 1

Eighty-seven differentially expressed genes (DEGs), 54 upregulated genes and 33 downregulated genes, were identified from 3 profile datasets in the ABC samples compared with those in the GCB samples. The DEGs are listed from the largest to the smallest fold change in the table. GCB common markers. ABC common markers.

DEGs	Gene Names
ABC Down-regulated	MYBL1, MME, LINC00487, C17orf99, STAG3, BTNL9,; STAP1, CCDC85A, RP11-138I18.2, SSBP2, IGHE, SEL1L3,; SNX29P1, CILP, SPINK2, MARCKSL1, ITPKB, MAML3,; SPRED2, ASB13, HOPX, CRNDE, LRMP, ZFAND4,; TEX9, NLRP4, DEF8, LMO2, SLC30A4,; POSTN, HLA-DOB, TOX, CDK14
ABC Up-regulated	IGHM, XK, KIAA0226L, MIR155 (MIR155HG), CLECL1,; AICDA, TNFRSF13B, BATF, FAM129C, FOXP1,; C1orf186 (LOC101929219), P2RX5, FUT8, IRF4, CYB5R2,; SFN, TBC1D27, JADE3, PARP15, ADTRP, MNDA, FCRL5,; FAM46C, MPEG1, BLNK, CD44, CCND2,; BTBD19, EHHADH,RAB29, CCDC50, DHRS9,; CHST2, S100A8, SLA, CFLAR, PIM2,; STAT3, ELL2, IL2RA, ETV6, NFKBIZ, ENTPD1,; HSP90B1 (MIR3652), LIMD1, ACTG2, TGIF1,; SLC2A13, ABHD17C, RNF183, TCF4, CCR10, BCL2A1