Identification of Hub Genes and Key Pathways Associated with Two Subtypes of Diffuse Large B-Cell Lymphoma Based on Gene Expression Profiling via Integrated Bioinformatics

Table 2

Analysis of significant enrichment of DEGs in DLBCL.

Term	Description	Count	P Value	Genes
Biological process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	10	0.008568	BATF, SSBP2, LMO2, MAML3, IRF4, MYBL1, ETV6, TCF4, FOXP1, STAT3
GO:0043066	negative regulation of apoptotic process	7	0.006042	CFLAR, HSP90B1, CD44, CCND2, BCL2A1, PIM2, STAT3
GO:0006954	inflammatory response	6	0.012073	NFKBIZ, IL2RA, NLRP4, S100A8, CHST2, BLNK
GO:0050853	B cell receptor signaling pathway	3	0.016456	IGHE, MNDA, IGHM
GO:0009967	positive regulation of signal transduction	3	0.020706	STAP1, BLNK, SLA
Cell component
GO:0005634	nucleus	28	0.081986	CYB5R2, S100A8, LMO2, ITPKB, MYBL1, SFN, BATF, STAG3, LIMD1…
GO:0005737	cytoplasm	27	0.089649	FUT8, MARCKSL1, EHHADH, MME, POSTN, SFN, BATF, ACTG2, CD44…
Molecular function
GO:0005515	protein binding	43	0.027431	CYB5R2, S100A8, LMO2, MARCKSL1, EHHADH, SPINK2, XK…
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding	9	6.28E-05	BATF, SSBP2, TGIF1, IRF4, MYBL1, ETV6, TCF4, FOXP1, STAT3
GO:0001077	transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding	7	2.91E-04	BATF, SSBP2, IRF4, MYBL1, ETV6, TCF4, STAT3
GO:0005515	protein kinase binding	5	0.056821	STAP1, CCND2, SPRED2, SFN, STAT3
GO:0005070	SH3/SH2 adaptor activity	3	0.019671	STAP1, BLNK, SLA