Identification of Hub Genes and Key Pathways Associated with Two Subtypes of Diffuse Large B-Cell Lymphoma Based on Gene Expression Profiling via Integrated Bioinformatics

Table 6

Enriched GO terms for the functions of the genes in the module.

#Pathway ID	Pathway description	Observed gene count	False discovery rate
GO.0050789	regulation of biological process	26	0.000803
GO.0048522	positive regulation of cellular process	25	2.51E-09
GO.0007165	signal transduction	25	9.18E-09
GO.0050794	regulation of cellular process	25	0.00158
GO.0044700	single organism signaling	24	1.99E-07
GO.0007154	cell communication	24	2.87E-07
GO.0051716	cellular response to stimulus	24	4.96E-06
GO.0010604	positive regulation of macromolecule metabolic process	22	2.02E-10
GO.0031325	positive regulation of cellular metabolic process	22	6.15E-10
GO.0050896	response to stimulus	22	0.00107
GO.0005829	cytosol	18	5.20E-05
GO.0005886	plasma membrane	17	0.0135
GO.0071944	cell periphery	17	0.0145
GO.0044459	plasma membrane part	13	0.00282
GO.0098552	side of membrane	11	2.81E-08
GO.0098589	membrane region	9	0.00338
GO.0045121	membrane raft	8	2.13E-06
GO.0009986	cell surface	8	0.00185
GO.0009897	external side of plasma membrane	7	2.37E-05
GO.1902494	catalytic complex	7	0.035
GO.0005515	protein binding	29	6.77E-12
GO.0005488	binding	28	0.0053
GO.0019899	enzyme binding	15	7.63E-07
GO.0005102	receptor binding	10	0.00191
GO.0060089	molecular transducer activity	10	0.0262
GO.0004672	protein kinase activity	7	0.00611
GO.0019904	protein domain specific binding	6	0.00546
GO.0019902	phosphatase binding	5	0.000899
GO.0019207	kinase regulator activity	5	0.00168
GO.0005126	cytokine receptor binding	5	0.00546