In Vitro Activity of β-Lactams in Combination with β-Lactamase Inhibitors against Mycobacterium tuberculosis Clinical Isolates

Table 3

MIC profiles of β-lactams alone or in combination with inhibitors against six MTB isolates.

Inhibitors

Concentration

MIC range (μg/ml)

TBM

MEM

DOR

BIA

ETP

AMX

AMP

MET

OXA

CLO

NAF

DIC

PIP

LEX

CXM

CFM

CPO

ATM

MOX

Clavulanate

0

8-16

16-32

8-16

8-16

32->32

64->128

>64

>128

128->128

>128

>128

>128

>128

64->128

>64

>128

64->128

>128

>128

0.625

<1-2

4-8

8-16

8-16

16-32

16-32

32-64

128->128

128->128

128->128

>128

>128

>128

64->128

32->64

>128

64->128

>128

>128

1.25

<1

4

4-8

4-8

16-32

8-32

16-64

64->128

128->128

128->128

>128

>128

>128

32->128

16-64

>128

32->128

>128

>128

2.5

<1

2-4

4-8

2-4

8-32

4-32

4-64

32->128

64->128

128->128

>128

>128

>128

32->128

16-32

>128

32->128

>128

>128

5

<1

2-4

2-4

1-2

8-16

4-8

<1-32

16->128

32->128

64->128

64->128

>128

64->128

16->128

4-16

>128

16->128

>128

>128

10

<1

2-4

2-4

1-2

8-16

4-8

<1-32

16->128

32->128

64->128

64->128

>128

64->128

16->128

4-16

>128

16->128

>128

>128

Avibactam

0

8-16

16-32

8-16

8-16

32->32

64->128

>64

>128

128->128

>128

>128

>128

>128

64->128

>64

>128

64->128

>128

>128

0.625

4-8

8-16

8-16

8-16

16->32

64-128

32-64

128->128

128->128

128->128

>128

>128

>128

32->128

32->64

>128

32->128

>128

>128

1.25

2-4

8-16

4-16

8-16

16-32

32-128

16-64

128->128

128->128

128->128

>128

>128

>128

32->128

32-64

>128

32->128

>128

>128

2.5

<1-4

8-16

4-8

4-8

8-32

32-64

8-64

64->128

64->128

128->128

>128

>128

>128

32->128

16-32

>128

32->128

>128

>128

5

<1-2

4-16

2-4

2-4

8-16

8-32

8-32

32->128

64->128

128->128

64->128

>128

>128

32->128

8-32

>128

32->128

>128

>128

10

<1-2

4-16

2-4

2-4

8-16

8-32

4-32

32->128

64->128

128->128

64->128

>128

>128

32->128

8-32

>128

32->128

>128

>128

Sulbactam

0

8-16

16-32

8-16

8-16

32->32

64->128

>64

>128

128->128

>128

>128

>128

>128

64->128

>64

>128

64->128

>128

>128

0.625

8-16

16-32

8-16

8-16

32->32

64->128

32-64

128->128

128->128

>128

>128

>128

>128

32->128

32->64

>128

32->128

>128

>128

1.25

4-16

16-32

8-16

4-16

16-32

64->128

16-64

64->128

64->128

128->128

>128

>128

>128

32->128

32-64

>128

32->128

>128

>128

2.5

4-8

16-32

4-16

4-8

16-32

32->128

8-64

32->128

64->128

128->128

64->128

>128

>128

32->128

16-32

>128

32->128

>128

>128

5

2-8

8-32

4-8

2-8

8-32

16->64

4-64

16->128

32->128

128->128

64->128

>128

>128

32->128

8-32

>128

32->128

>128

>128

10

2-8

8-32

4-8

2-8

8-32

16->64

4-64

16->128

32->128

64->128

64->128

>128

>128

32->128

8-32

>128

32->128

>128

>128

Note: TBM, tebipenem; MEM, meropenem; DOR, doripenem; BIA, biapenem; ETP, ertapenem; AMX, amoxicillin; AMP, ampicillin; MET, methicillin; OXA, oxacillin; CLO, cloxacillin; NAF, nafcillin; DIC, dicloxacillin; PIP, piperacillin; LEX, cephalexin; CXM, cefuroxime; CFM, cefixime; CPO, cefpirome; ATM, aztreonam; MOX, moxalactam.