Artificial Neural Network to Predict Varicocele Impact on Male Fertility through Testicular Endocannabinoid Gene Expression Profiles

Table 2

Univariate correlation among reproductive outcomes and ECS gene expression levels in left and right testes.

						Left							Right
		N. of pups	NAPE-PLD	FAAH	DAGL	MAGL	CB1	CB2	TRPV1	NAPE-PLD	FAAH	DAGL	MAGL	CB1	CB2	TRPV1
	N. of pups		0.912	0.999	0.364	0.160	0.183	0.199	0.023	0.588	0.838	0.695	0.930	0.447	0.781	0.622
	NAPE-PLD	-0.019		^a0.003	0.065	^b1.2x10^-5	0.787	0.602	0.207	^c0.036	0.348	0.053	0.195	0.693	0.232	0.384
	FAAH	0.0002	^a0.494		0.309	^d0.0002	^e0.042	0.075	0.841	0.886	^f0.017	0.067	0.162	0.652	^g0.048	0.0775
	DAGL	-0.158	0.315	0.177		0.384	^h0.012	^i4.9x10^-5	^j0.023	0.843	0.574	^k0.019	0.133	0.906	0.249	0.284
Left	MAGL	-0.243	^b0.668	^d0.591	0.152		0.503	0.790	^l0.005	0.346	0.797	0.813	0.903	0.951	0.727	0.842
	CB1	0.231	0.047	^e0.346	^h0.418	-0.117		^m2.9x10^-11	^n 5.9x10^-6	0.090	0.402	0.071	0.813	0.0552	0.131	0.184
	CB2	0.222	0.091	0.305	^i0.630	-0.047	^m0.862		^o7.6x10^-8	0.085	0.463	0.105	0.421	0.380	0.202	0.179	p
	TRPV1	0.383	-0.219	-0.035	^j0.384	^l-0.462	^n0.684	^o0.767		0.214	0.341	^p0.049	0.505	0.309	0.318	0.246
	NAPE-PLD	-0.095	^c0.356	0.025	-0.035	0.164	-0.291	-0.296	-0.216		0.625	^q0.027	0.489	0.800	0.678	0.182
	FAAH	0.036	0.163	^f0.402	0.098	-0.045	0.146	0.128	0.166	-0.085		^r0.006	0.725	0.105	^s1.7x10^-9	^t9.6x10^-8
	DAGL	0.069	0.330	0.313	^k0.395	0.041	0.309	0.279	^p0.335	^q0.374	^r0.451		0.294	^u0.047	^v0.018	0.062
Right	MAGL	-0.015	-0.224	-0.242	-0.259	-0.021	-0.042	-0.140	-0.117	-0.121	-0.062	-0.182		^w0.0001	0.935	0.542
	CB1	-0.133	-0.069	0.079	-0.021	-0.011	0.327	0.153	0.177	-0.044	0.278	^u0.339	^w0.607		^x0.007	^y0.002
	CB2	-0.049	0.207	^g0.336	0.200	-0.061	0.260	0.221	0.174	-0.073	^s0.820	^v0.399	-0.014	^x0.447		^z2.2x10^-11
	TRPV1	-0.086	0.152	0.302	0.186	-0.035	0.230	0.232	0.201	-0.231	^t0.764	0.319	0.107	^y0.499	^z0.865

Lower-left corner: Pearson correlation r coefficient. Upper-right corner: correlation analysis p values. The underlined values express a significant correlation between TRPV1 expression in left testes and reproductive outcomes, as indicated by r and p coefficients. ^a-zSuperscripts indicate significant correlations either of single ECS gene expression level of left versus right testes or among different ECS gene expression levels recorded intra and inter testes. Bold data were considered statistically significant for p values < 0.05.