Artificial Neural Network to Predict Varicocele Impact on Male Fertility through Testicular Endocannabinoid Gene Expression Profiles
Table 2
Univariate correlation among reproductive outcomes and ECS gene expression levels in left and right testes.
Left
Right
N. of pups
NAPE-PLD
FAAH
DAGL
MAGL
CB1
CB2
TRPV1
NAPE-PLD
FAAH
DAGL
MAGL
CB1
CB2
TRPV1
N. of pups
0.912
0.999
0.364
0.160
0.183
0.199
0.023
0.588
0.838
0.695
0.930
0.447
0.781
0.622
NAPE-PLD
-0.019
a0.003
0.065
b1.2x10-5
0.787
0.602
0.207
c0.036
0.348
0.053
0.195
0.693
0.232
0.384
FAAH
0.0002
a0.494
0.309
d0.0002
e0.042
0.075
0.841
0.886
f0.017
0.067
0.162
0.652
g0.048
0.0775
DAGL
-0.158
0.315
0.177
0.384
h0.012
i4.9x10-5
j0.023
0.843
0.574
k0.019
0.133
0.906
0.249
0.284
Left
MAGL
-0.243
b0.668
d0.591
0.152
0.503
0.790
l0.005
0.346
0.797
0.813
0.903
0.951
0.727
0.842
CB1
0.231
0.047
e0.346
h0.418
-0.117
m2.9x10-11
n 5.9x10-6
0.090
0.402
0.071
0.813
0.0552
0.131
0.184
CB2
0.222
0.091
0.305
i0.630
-0.047
m0.862
o7.6x10-8
0.085
0.463
0.105
0.421
0.380
0.202
0.179
p
TRPV1
0.383
-0.219
-0.035
j0.384
l-0.462
n0.684
o0.767
0.214
0.341
p0.049
0.505
0.309
0.318
0.246
NAPE-PLD
-0.095
c0.356
0.025
-0.035
0.164
-0.291
-0.296
-0.216
0.625
q0.027
0.489
0.800
0.678
0.182
FAAH
0.036
0.163
f0.402
0.098
-0.045
0.146
0.128
0.166
-0.085
r0.006
0.725
0.105
s1.7x10-9
t9.6x10-8
DAGL
0.069
0.330
0.313
k0.395
0.041
0.309
0.279
p0.335
q0.374
r0.451
0.294
u0.047
v0.018
0.062
Right
MAGL
-0.015
-0.224
-0.242
-0.259
-0.021
-0.042
-0.140
-0.117
-0.121
-0.062
-0.182
w0.0001
0.935
0.542
CB1
-0.133
-0.069
0.079
-0.021
-0.011
0.327
0.153
0.177
-0.044
0.278
u0.339
w0.607
x0.007
y0.002
CB2
-0.049
0.207
g0.336
0.200
-0.061
0.260
0.221
0.174
-0.073
s0.820
v0.399
-0.014
x0.447
z2.2x10-11
TRPV1
-0.086
0.152
0.302
0.186
-0.035
0.230
0.232
0.201
-0.231
t0.764
0.319
0.107
y0.499
z0.865
Lower-left corner: Pearson correlation r coefficient. Upper-right corner: correlation analysis p values. The underlined values express a significant correlation between TRPV1 expression in left testes and reproductive outcomes, as indicated by r and p coefficients. a-zSuperscripts indicate significant correlations either of single ECS gene expression level of left versus right testes or among different ECS gene expression levels recorded intra and inter testes. Bold data were considered statistically significant for p values < 0.05.