Calcitriol Prevents Cardiovascular Repercussions in Puromycin Aminonucleoside-Induced Nephrotic Syndrome
Table 1
Body weight, metabolic balance, and renal function in control (Ct-V and Ct-D) and nephrotic (PAN-V and PAN-D) rats, after 21 days of calcitriol or vehicle treatments.
Day 21
Ct-V
Ct-D
PAN-V
PAN-D
Body weight (g)
240 ± 3
237 ± 5
Food intake (g/24 h)
0.02 ± 0.00
0.02 ± 0.00
0.02 ± 0.00
0.02 ± 0.00
P proteins (g/L)
52.7 ± 3.4
51.4 ± 0.4
48.8 ± 2.6
53.0 ± 2.5
U proteins (mg/24 h)
15.3 ± 2.4
17.0 ± 2.2
Na+ intake (mmol/24 h)
1.65 ± 0.00
1.65 ± 0.00
1.65 ± 0.00
1.65 ± 0.00
P Na+ (mmol/L)
146 ± 5
149 ± 2
143 ± 3
150 ± 1
U Na+ (mmol/24 h)
1.31 ± 0.23
1.40 ± 0.05
1.38 ± 0.14
1.44 ± 0.09
Na+ balance (mmol/24 h)
0.35 ± 0.23
0.26 ± 0.05
0.27 ± 0.14
0.21 ± 0.09
FE Na+ (%)
0.34 ± 0.07
0.67 ± 0.23
0.57 ± 0.10
0.60 ± 0.16
P Ca2+ (mmol/L)
2.45 ± 0.15
2.84 ± 0.47
3.03 ± 0.09
U Ca2+ (mmol/24 h)
0.26 ± 0.12
0.04 ± 0.02
0.01 ± 0.00
0.02 ± 0.01
FE Ca2+ (%)
4.57 ± 3.00
3.58 ± 1.77
0.17 ± 0.03
0.52 ± 0.20
P P (mmol/L)
2.96 ± 0.24
3.33 ± 0.39
3.10 ± 0.23
3.52 ± 0.16
U P (mmol/24 h)
0.06 ± 0.04
0.12 ± 0.03
0.08 ± 0.05
0.10 ± 0.03
FE P (%)
0.53 ± 0.23
1.37 ± 0.43
0.43 ± 0.21
1.27 ± 0.26
P creatinine (mg/L)
3.73 ± 0.29
5.07 ± 0.58
4.70 ± 0.59
3.27 ± 0.61
C creatinine (mL/min)
2.44 ± 0.74
1.76 ± 0.15
1.49 ± 0.27
1.75 ± 0.59
P ALP (U/I)
147 ± 23
141 ± 8
101 ± 21
Values are means ± SE; to 4 experiments per group. P, plasma; U, urine; FE, fractional excretion; and C, clearance. , significantly different from values in the corresponding control groups (Ct-V or Ct-D); , significantly different from corresponding values in PAN-V group.
