Research Article

A Meta-Analysis Characterizing Stem-Like Gene Expression in the Suprachiasmatic Nucleus and Its Circadian Clock

Table 2

SCN-enriched transcription regulator genes identified by Hatori et al., 2014 [38].

Gene symbol and namePANTHER GO Biological Process (GO BP Complete)Circadian phase (hours)LD phase (hours)Fluctuating in LD

Dlx2 (distal-less homeobox 2)cerebral cortex GABAergic interneuron differentiation and fate commitment, negative regulation of Notch signaling pathwayND8No
Dlx6 (distal-less homeobox 6)inner ear morphogenesis, epithelial cell differentiation, positive regulation of epithelial cell proliferationND8Yes
Foxd1 (forkhead box D1)axon guidance, positive regulation of kidney development, positive regulation of bone morphogenetic protein signalingND6No
Lhx1 (LIM homeobox protein 1)nervous system development, cerebellar Purkinje cell differentiation, cell-cell signaling, embryonic retina morphogenesis in camera-type eyeND6No
Nr2f2 (nuclear receptor subfamily 2, group F, member 2)neuron migration, forebrain development, anterior/posterior pattern specification106Yes
Rora (RAR-related orphan receptor alpha)cerebellar granule cell precursor proliferation, cerebellar Purkinje cell differentiation, circadian regulation of gene expression, cellular response to tumor necrosis factor, regulation of smoothened signaling pathway, negative regulation of fat cell differentiation, muscle cell differentiation, T-helper 17 cell differentiation(7)6Yes
Rorb (RAR-related orphan receptor beta)amacrine cell differentiation, retina development in camera-type eye, regulation of circadian rhythm60Yes
Six3 (sine oculis-related homeobox 3)negative regulation of neuron differentiation, circadian behavior, neuroblast differentiation and migration, negative regulation of Wnt signaling pathwayND6Yes
Sox1 (SRY (sex determining region Y)-box 1)neuron migration, forebrain neuron differentiation, nervous system, developmentND6Yes
Sox11 (SRY (sex determining region Y)-box 11)positive regulation of neuron differentiation, glial cell development, positive regulation of neurogenesis, positive regulation of hippo signaling, positive regulation of stem cell proliferation(15.5)6No
Tle4 (transducin-like enhancer of split 4)Wnt signaling pathwayND2Yes

Boldface indicates genes also listed in Table 1. Circadian phases are from CircaDB. ND = no significant rhythm detected in CircaDB using the JTK test. () = average phase when phases from more than one experiment were reported for a rhythm in the SCN. Acceptable circadian periods were between 19-30 hours. Phases in light/dark cycle (LD) and significance of daily fluctuations are from SCNseq.