A Meta-Analysis Characterizing Stem-Like Gene Expression in the Suprachiasmatic Nucleus and Its Circadian Clock
Table 3
Fold change in gene expression in the SCN relative to contrast areas examined through Differential Search analysis.
Gene symbol
Fold change in the SCN compared to contrast region
SO
LPO
PVH
PVHd
ARH
DG
Btg1
9.097
4.689
1.579
4.099
0.339
0.231
Cdh13
3.554-6.873
1.585-2.852
2.704
1.033-3.584
1.291-23.019
2.509-4.947
Dlk1
4.535
4.479
1.628
1.32
1.067
123.262
Flrt3
25.477
2.969
14.839
5.19
3.383
0.721
Igfbp5
10.391
7.541
3.416
2.868
2.321
1.34
Lhx1
NE
NE
NE
NE
NE
NE
Msi2
5.175
2.019
2.333
10.993
2.456
3.7
Myt1
3.055
2.825
1.323
1.08
1.062
0.944
Neurod2
3.517
4.373
2.807
NA
3.845
0.855
Nkd1
1.964
5.242
0.88
0.7
2.079
2.685
Nr2f2
2.292
4.411
NE
4.844
1.476
2.362
Pcsk2
3.872
NE
0.941
1.028
1.506
0.944
Rora
16.865-29.842
22.593-22.99
3.44-9.991
1.919-6.545
16.377-18.926
8.694-11.126
Rorb
35.538
19.534
8.161
18.822
9.207
32.208
Spon1
1.629
1.865
1.562
1.076
0.82
0.612
Thsd7b
4.586
0.755
0.566
NE
4.101
1.595
Tle4
40.204
13.117
NE
20.09
3.658
0.915
Zfhx3
5.525
3.685
2.379
1.803
1.659
9.041
Zic1
2.47
1.839
0.639
NE
29.025
2.416
% of genes with higher SCN expression
100
94.7
78.9
94.4
89.5
63.2
Boldface indicates where the contrast area had higher expression. The range of fold change is shown when more than one experiment was available for comparison. The maximum number of experiments per gene was three or less. NE: no significant expression in the contrast area. NA: target area expression was not available. SO: supraoptic nucleus, LPO: lateral preoptic area, PVH: paraventricular hypothalamic nucleus, PVHd: PVH descending division, ARH: arcuate nucleus of the hypothalamus, and DG: dentate gyrus.
