Chronic Intake of Commercial Sweeteners Induces Changes in Feeding Behavior and Signaling Pathways Related to the Control of Appetite in BALB/c Mice

Table 1

Food, water, and energy intake. Data are expressed as mean ± SEM. compared to control group in each week (differences between means with a 95% confidence interval). male and 9 female animals per group.

Week	Group	Food intake (g)	Water intake (g)	Energy intake (Kcal)	Food intake (g)	Water intake (g)	Energy intake (Kcal)
		Male			Female
1	Control	5.22 ± 0.43	6.02 ± 0.14	23.13 ± 1.76	3.48 ± 0.85	4.74 ± 0.50	14.24 ± 3.50
	SG	4.12 ± 0.62	4.91 ± 0.54	16.83 ± 1.34	4.02 ± 0.57	4.37 ± 0.55	16.45 ± 2.35
	Sucralose	3.80 ± 0.01	5.20 ± 0.4	15.55 ± 0.06	4.41 ± 0.49	4.47 ± 0.21	18.07 ± 2.01
	Sucrose	2.6 ± 0.3	11.75 ± 1.31	16.13 ± 0.69	2.83 ± 0.19	9.36 ± 2.55	15.32 ± 1.56
2	Control	5.41 ± 0.18	6.08 ± 0.03	22.91 ± 0.77	4.14 ± 0.37	4.99 ± 0.68	16.95 ± 1.51
	SG	3.99 ± 0.41	4.44 ± 0.22	16.30 ± 1.68	3.61 ± 0.33	3.8 ± 0.27	14.78 ± 1.35
	Sucralose	4.33 ± 0.31	6.12 ± 0.79	17.73 ± 1.28	4.51 ± 0.36	4.78 ± 0.39	18.46 ± 1.49
	Sucrose	2.55 ± 0.23	12.7 ± 2.43	15.54 ± 1.07	3.16 ± 0.40	11.36 ± 3.5	17.47 ± 2.91
3	Control	4.55 ± 0.33	5.94 ± 0.18	19.96 ± 1.36	3.93 ± 0.47	4.51 ± 0.08	16.08 ± 1.92
	SG	4.14 ± 0.47	4.24 ± 0.28	16.94 ± 1.92	3.55 ± 0.02	3.67 ± 0.13	14.55 ± 0.11
	Sucralose	4.06 ± 0.28	5.05 ± 0.23	16.61 ± 1.14	3.95 ± 0.56	4.27 ± 0.59	16.18 ± 2.31
	Sucrose	2.84 ± 0.19	11.61 ± 2.86	16.27 ± 1.87	2.46 ± 0.20	9.27 ± 2.5	13.78 ± 1.54
4	Control	4.70 ± 0.06	5.99 ± 0.18	18.99 ± 0.23	3.80 ± 0.22	4.46 ± 0.20	15.57 ± 0.90
	SG	3.84 ± 0.12	4.63 ± 0.82	15.73 ± 0.49	3.47 ± 0.12	3.6 ± 0.14	14.20 ± 0.52
	Sucralose	4.10 ± 0.31	5.05 ± 0.35	16.80 ± 1.3	3.45 ± 0.62	4.75 ± 0.68	14.13 ± 2.5
	Sucrose	2.82 ± 0.33	15.12 ± 0.98	17.62 ± 1.11	2.62 ± 0.20	9.4 ± 1.32	14.49 ± 1.01
5	Control	5.32 ± 0.30	5.84 ± 0.03	20.53 ± 1.23	4.00 ± 0.42	4.4 ± 0.37	16.37 ± 1.72
	SG	3.95 ± 0.15	4.64 ± 0.66	16.15 ± 0.62	4.3 ± 0.95	3.49 ± 0.70	17.61 ± 3.9
	Sucralose	4.42 ± 0.51	5.5 ± 0.80	18.09 ± 2.09	4.01 ± 0.46	4.53 ± 0.54	16.43 ± 1.9
	Sucrose	2.54 ± 0.22	14.27 ± 1.44	16.10 ± 0.43	2.50 ± 0.54	11.6 ± 3.36	14.88 ± 1.02
6	Control	4.55 ± 0.21	5.71 ± 0.22	19.46 ± 0.85	4.54 ± 0.28	5.02 ± 0.24	18.61 ± 1.16
	SG	3.77 ± 0.19	4.22 ± 0.66	15.39 ± 0.80	3.6 ± 0.44	4.62 ± 1.03	15.02 ± 1.82
	Sucralose	4.1 ± 0.88	4.88 ± 0.98	16.79 ± 2.09	3.82 ± 0.09	4.45 ± 0.06	15.66 ± 0.36
	Sucrose	2.57 ± 0.28	14.05 ± 1.56	16.14 ± 0.65	2.50 ± 0.25	10.75 ± 3.3	14.56 ± 1.47