Research Article

Chronic Intake of Commercial Sweeteners Induces Changes in Feeding Behavior and Signaling Pathways Related to the Control of Appetite in BALB/c Mice

Table 2

Weight and weight change per weeks of treatment. Data are expressed as mean ± SEM. compared to control group in each week (differences between means with a 95% confidence interval).   male and 9 female animals per group.

WeekGroupWeight (gm)Weight change (gm)Weight (gm)Weight change (gm)
MaleFemale

0Control22.00 ± 0.69/19.63 ± 0.31/
SG23.1 ± 0.62/18.16 ± 0.45/
Sucralose24.2 ± 0.56/19.02 ± 0.54/
Sucrose24.42 ± 1.32/18.35 ± 0.51/

1Control23.42 ± 0.611.42 ± 0.4120.1 ± 0.420.46 ± 0.28
SG23.55 ± 0.590.45 ± 0.2018.86 ± 0.530.68 ± 0.12
Sucralose25.28 ± 0.591.08 ± 0.1118.41 ± 0.88−0.61 ± 0.39
Sucrose25.9 ± 1.261.47 ± 0.2219.64 ± 0.551.28 ± 0.27

2Control23.81 ± 0.601.81 ± 0.4620.45 ± 0.610.82 ± 0.61
SG24.07 ± 0.670.97 ± 0.2519.73 ± 0.451.56 ± 0.18
Sucralose25.04 ± 0.760.84 ± 0.3219.8 ± 0.580.77 ± 0.15
Sucrose25.72 ± 1.111.3 ± 0.3820.2 ± 0.601.84 ± 0.49

3Control24.16 ± 0.452.16 ± 0.5221.57 ± 0.551.94 ± 0.46
SG24.04 ± 0.630.94 ± 0.2620.31 ± 0.442.14 ± 0.21
Sucralose26.10 ± 0.651.9 ± 0.3321.37 ± 0.272.35 ± 0.36
Sucrose26.48 ± 0.882.05 ± 0.5521.04 ± 0.552.68 ± 0.57

4Control24.17 ± 0.562.17 ± 0.4822.01 ± 0.552.37 ± 0.47
SG24.47 ± 0.571.36 ± 0.3021.01 ± 0.412.84 ± 0.15
Sucralose27 ± 0.712.8 ± 0.4222.72 ± 0.643.7 ± 0.74
Sucrose26.48 ± 1.012.46 ± 0.4522.27 ± 0.53.92 ± 0.35

5Control24.17 ± 0.472.17 ± 0.5421.87 ± 0.332.24 ± 0.19
SG24.63 ± 0.471.53 ± 0.2621.04 ± 0.472.87 ± 0.20
Sucralose27.87 ± 0.693.67 ± 0.3722.28 ± 0.403.26 ± 0.69
Sucrose27.36 ± 1.062.94 ± 0.4222.41 ± 0.534.05 ± 0.32

6Control24.38 ± 0.442.38 ± 0.5222.81 ± 0.583.17 ± 0.56
SG24.61 ± 0.491.51 ± 0.3320.81 ± 0.462.65 ± 0.19
Sucralose27.13 ± 0.672.92 ± 0.6322.66 ± 0.273.64 ± 0.64
Sucrose27.33 ± 0.92.91 ± 0.5322.58 ± 0.524.23 ± 0.39