Biatrial versus Isolated Left Atrial Ablation in Atrial Fibrillation: A Systematic Review and Meta-Analysis

Table 2

Characteristics of the studies that were initially included in the meta-analysis.

First author	Year	Country	Study period	Type of study	Follow-up (MO)	(BA)	(LA)	Type of ablation	Lesion set	Cardiac operation
Gualis	2016	Spain	2006–2011	R	36	67	83	CY	PVI, LAA, RAA, TC, CS, WG	AVR AVP MVR MVP TVP
Liu	2015	China	2012-2012	R	3–12R	86	111	RF	PVI, LAA, RAA	MVR DVR TVP
Henn	2015	USA	2002–2014	P, non-RCT	5 years	532	44	RF	PVI, LAA, RAA, TC, CS, WG	AVR CABG MVR MVP TVP
Pecha	2014	Germany	2008–2011	R	12	66	66	RF, CY	LVI, LAA, CI, RAA, TC	CABG AVR MVR TVR
Jiang	2014	China	2008–2012	R	NR	61	48	RF	PVI, MV, LAA, RAA, TC, CS, WG	MVR MVP TVP
Soni	2013	USA	2007–2011	R	12	91	214	RF, CY, MW	PVI, PW, MI, LAA MM	AVR MVR CABG MVP TVP
Pecha	2014	Germany	2003–2012	R	30 days	131	463	CY, RF	LVI, LAA, BLI, CI, RAA, TC	AVR AVP MVR MVP TVP CABG ASD VSD
Onorati	2011	Italy	2003–2008	P, non-RCT	15	109	32	RF	PVI MV LAA RAA TC CS WG	AVR AVP MVR MVP TVP
Kim	2011	South Korea	2006–2009	R	26 ± 13.3	199	82	CY	PVI, PW, MI, LAA, MM, CS	AVR AVP MVR MVP TVP CABG ASD VSD
Breda	2011	Brazil	2003–2009	R	12.16 ± 10.89	15	15	RF	PVI, PW, MI, LAA, MM	MVR MVP
Albage	2011	Sweden	2005–2010	P, non-RCT	1–12R	44	71	CY	PVI, PW, MI, LAA, Maze III	AVR CABG MVP TVP MVR ASD MVP
McCarthy	2010	USA	2004–2008	P, non-RCT	5–24R	91	75	RF, CY, cut-and-sew	PVI LAA RAA TC	AVR MVR TVP CABG
Deneke	2009	Germany	NR	R	55 ± 17	64	66	RF	PVI, PW, MI, LAA, Maze III	MVR, AVR, CABG
Wang	2009	China	2004–2007	P, RCT	28 ± 5	150	149	RF	PVI, PW, MI, LAA, CTI, MM	MVR AVR MVP TVR TVP AVP
Srivastava	2008	India	NR	P, RCT	44	40	40	RF, CY	PVI, PW, MI, LAA, Maze III	MVR AVR MVP TVR TVP AVP
Geuzebroek	2008	Netherlands	1999–2005	R	NR	26	40	RF	PVI, PW, MI, LAA, Maze III	MVR AVR MVP TVR TVP AVP
Deneke	2007	Germany	1997–2005	R	21	106	116	RF	PVI MV LAA RAA, MM	MVR MVP CABG AVR
Calo	2006	Italy	NR	P, RCT	15 ± 5 (BA)/13 ± 6 (LA)	39	41	RF	PVI MV LAA RAA TC CS WG	NR
Ryan	2004	USA	1996–2003	R	595 ± 750 days	36	7	RF, CY, cut-and-sew	PVI, PW, MI, LAA, Maze III	NR
Guden	2003	Turkey	2001	P, non-RCT	10.9 ± 5.58	48	57	RF	PVI, PW, MI, LAA, Maze III	AVR CABG MVP TVP MVR ASD MVP
Takami	1999	Japan	NR	R	34.1 ± 11.3 (BA)/17.8 ± 3.8 (LA)	30	20	CY, cut-and-sew	PVI, PW, MI, LAA, CTI, Maze III	MVR, CABG, AVR, TVR

MO: month; R: range; P: p retrospective observational; RCT: randomized, controlled trial; BA: biatrial ablation; LA: left atrial ablation; CY: cryoablation; RF: radiofrequency ablation; MW: microwave ablation; PVI: pulmonary vein isolation; LAA: left atrial appendage; RAA: right atrial appendage; TC: terminal crest; CS: coronary sinus; WG: Waterston’s groove; MI: mitral isthmus; MM: modified maze; CI: cavotricuspid isthmus; PW: posterior wall; AVR: aortic valve replacement; AVP: aortic valvuloplasty; MVR: mitral valve replacement; MVP: mitral valvuloplasty; TVP: tricuspid valvuloplasty; CABG: coronary artery bypass grafting; ASD: atrial septal defect repair; VSD: ventricular septal defect repair; NR: no report.