Novel Intravaginal Drug Delivery System Based on Molecularly PEGylated Lipid Matrices for Improved Antifungal Activity of Miconazole Nitrate

Figure 2

Fourier transform infrared (FT-IR) spectra of miconazole nitrate (MN) (a) and MN-loaded non-PEGylated and PEGylated lipid matrices (b and c) and selected miconazole nitrate-loaded SLMs (d). Note: non-PEGylated lipid matrix (LM 1:9) prepared with super-refined sunseed oil (10 %w/w) and Softisan® 154 (90 %w/w) and PEGylated lipid matrix [PEG-LM 1:9 (4:6)] made with PEG 4000 (40 %w/w) and LM 1:9 (60 %w/w) were used.

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