Novel Intravaginal Drug Delivery System Based on Molecularly PEGylated Lipid Matrices for Improved Antifungal Activity of Miconazole Nitrate

Figure 3

Viscosity profiles of optimized miconazole nitrate-loaded SLMs. Key: batch AM₃ is optimized MN-loaded non-PEGylated SLMs containing 3.0 %w/w of miconazole nitrate, and batches B-D are PEGylated SLMs containing increasing concentrations (1.0, 2.0 and 4.0 %w/w) of PEG 4000, respectively; AM₃–DM₃ contain 3.0 %w/w of miconazole nitrate, while unloaded is plain SLM.