BioMed Research International

Research Article

Novel Intravaginal Drug Delivery System Based on Molecularly PEGylated Lipid Matrices for Improved Antifungal Activity of Miconazole Nitrate

Table 1

Formulation composition of lipid matrices for SLMs preparation.
SampleIngredients (%w/w)
LM 1:1Super-refined sunseed oil (50) and Softisan® 154 (50)
LM 1:3Super-refined sunseed oil (33.33) and Softisan® 154 (66.67)
LM 1:6Super-refined sunseed oil (16.67) and Softisan® 154 (83.33)
LM 1:9Super-refined sunseed oil (10) and Softisan® 154 (90)
PEG-LM 1:1 (1:9)PEG 4000 (10) and Lipid matrix, LM 1:1 (90)
PEG-LM 1:1 (2:8)PEG 4000 (20) and Lipid matrix, LM 1:1 (80)
PEG-LM 1:1 (4:6)PEG 4000 (40) and Lipid matrix, LM 1:1 (60)
PEG-LM 1:3 (1:9)PEG 4000 (10) and Lipid matrix, LM 1:3 (90)
PEG-LM 1:3 (2:8)PEG 4000 (20) and Lipid matrix, LM 1:3 (80)
PEG-LM 1:3 (4:6)PEG 4000 (40) and Lipid matrix, LM 1:3 (60)
PEG-LM 1:6 (1:9)PEG 4000 (10) and Lipid matrix, LM 1:6 (90)
PEG-LM 1:6 (2:8)PEG 4000 (20) and Lipid matrix, LM 1:6 (80)
PEG-LM 1:6 (4:6)PEG 4000 (40) and Lipid matrix, LM 1:6 (60)
PEG-LM 1:9 (1:9)PEG 4000 (10) and Lipid matrix, LM 1:9 (90)
PEG-LM 1:9 (2:8)PEG 4000 (20) and Lipid matrix, LM 1:9 (80)
PEG-LM 1:9 (4:6)PEG 4000 (40) and Lipid matrix, LM 1:9 (60)
Key: LM means lipid matrix prepared with super-refined sunseed oil and Softisan® 154; LM 1:1, LM 1:3, LM 1:6, and LM 1:9 are non-PEGylated lipid matrices containing increasing amounts of Softisan® 154; PEG-LM 1:1(1:9), PEG-LM 1:1(2:8), and PEG-LM 1:1(4:6) are PEGylated lipid matrices based on 1:1 ratio of sunseed oil and Softisan® 154 and containing increasing amounts of PEG 4000; PEG-LM 1:3(1:9), PEG-LM 1:3(2:8), and PEG-LM 1:3(4:6) are PEGylated lipid matrices based on 1:3 ratio of sunseed oil and Softisan® 154 and containing increasing amounts of PEG 4000; PEG-LM 1:6(1:9), PEG-LM 1:6(2:8), and PEG-LM 1:6(4:6) are PEGylated lipid matrices based on 1:6 ratio of sunseed oil and Softisan® 154 and containing increasing amounts of PEG 4000, while PEG-LM 1:9(1:9), PEG-LM 1:9(2:8), and PEG-LM 1:9(4:6) are PEGylated lipid matrices based on 1:9 ratio of sunseed oil and Softisan® 154 and containing increasing amounts of PEG 4000.