Novel Intravaginal Drug Delivery System Based on Molecularly PEGylated Lipid Matrices for Improved Antifungal Activity of Miconazole Nitrate

Table 3

Thermal properties of the lipid matrices for SLMs preparation.

Sample	Melting point; (°C)	Enthalpy (W/g)	Melting temperature range (°C)	Area (J/g)
Softisan® 154	61.40	- 8.9	37 – 75	71.92
LM 1:1	60.82	- 9.0	25 – 75	271.5
LM 1:3	61.62	- 2.5	25 – 75	61.19
LM 1:6	115.18	- 0.25	110 – 127	4.228
LM 1:9	64.56	- 2.05	25 – 75	47.63
PEG 4000	64.40	- 3.6	50 – 75	67.20
PEG-LM1:1 (1:9)	142.49	- 0.35	135 – 157	33.24
PEG-LM1:1 (2:8)	145.66	- 0.4	142 – 148	47.18
PEG-LM1:1 (4:6)	62.66	- 2.0	25 – 75	64.87
PEG-LM1:3 (1:9)	88.00	- 0.35	80 – 115	25.35
PEG-LM1:3 (2:8)	60.60	- 3.4	45 – 70	39.89
PEG-LM1:3 (4:6)	65.76	- 2.3	25 – 75	53.63
PEG-LM1:6 (1:9)	61.51	- 4.0	37 – 75	84.55
PEG-LM1:6 (2:8)	61.57	- 3.25	25 – 75	52.22
PEG-LM1:6 (4:6)	61.75	- 4.5	25 – 75	99.11
PEG-LM1:9 (1:9)	60.75	- 4.25	25 – 75	72.59
PEG-LM1:9 (2:8)	61.32	- 3.6	25 – 75	60.29
PEG-LM1:9 (4:6)	61.12	- 4.1	25 – 75	68.82

Key: LM 1:1, LM 1:3, LM 1:6, and LM 1:9 are non-PEGylated lipid matrices containing increasing amounts of Softisan® 154; PEG-LM 1:1(1:9), PEG-LM 1:1(2:8), and PEG-LM 1:1(4:6) are PEGylated lipid matrices based on 1:1 ratio of sunseed oil and Softisan® 154 and containing increasing amounts (10, 20, and 40 %w/w) of PEG 4000; PEG-LM 1:3(1:9), PEG-LM 1:3(2:8), and PEG-LM 1:3(4:6) are PEGylated lipid matrices based on 1:3 ratio of sunseed oil and Softisan® 154 and containing increasing amounts (10, 20, and 40 %w/w) of PEG 4000; PEG-LM 1:6(1:9), PEG-LM 1:6(2:8), and PEG-LM 1:6(4:6) are PEGylated lipid matrices based on 1:6 ratio of sunseed oil and Softisan® 154 and containing increasing amounts (10, 20, and 40 %w/w) of PEG 4000, while PEG-LM 1:9(1:9), PEG-LM 1:9(2:8), and PEG-LM 1:9(4:6) are PEGylated lipid matrices based on 1:9 ratio of sunseed oil and Softisan® 154 and containing increasing amounts (10, 20, and 40 %w/w) of PEG 4000.