Novel Intravaginal Drug Delivery System Based on Molecularly PEGylated Lipid Matrices for Improved Antifungal Activity of Miconazole Nitrate

Table 6

Cell killing parameters of optimized miconazole nitrate-loaded SLMs.

Formulation code	Death rate constant, K (min^−1)	D-value (min)
AM3	7.10 x 10^−3	120.000
BM3	8.80 x 10^−3	105.541
CM3	1.09 x 10^−2	81.026
DM3	1.09 x 10^−2	81.026
Fungusol® lotion	8.00 x 10^−3	109.389
MN pure sample suspension	5.60 x 10^−3	164.835

Key: AM₃ is optimized non-PEGylated SLMs containing 3.0 %w/w of miconazole nitrate; BM₃–DM₃ are PEGylated SLMs containing increasing concentrations (1.0, 2.0, and 4.0 %w/w) of PEG 4000, respectively, and 3.0 %w/w of miconazole nitrate; Fungusol® is commercial topical formulation of miconazole nitrate, while MN is pure miconazole nitrate sample.