Histogram Analysis of Perfusion Parameters from Dynamic Contrast-Enhanced MR Imaging with Tumor Characteristics and Therapeutic Response in Locally Advanced Rectal Cancer
Table 2
Correlation of histogram analysis of perfusion parameters with biologic aggressiveness.
Parameter
Reader 1
Reader 2
Yes (n = 24)
No (n = 13)
P value
Yes (n = 24)
No (n = 13)
P value
Biologic aggressiveness
AUC skewness
-0.4 (-0.7;-0.2)
-0.2 (-0.3;0.1)
0.016
0.744
-0.4(-0.6;-0.2)
-0.2(-0.3;0.2)
0.012
0.753
AUC kurtosis
-0.1 (-0.5;0.1)
-0.6 (-0.9;-0.1)
0.036
0.712
-0.4 (-0.6;0.2)
-0.6(-0.8;-0.1)
0.098
0.667
kurtosis
-0.2 (-0.6;0.4)
0.4 (-0.1;1.6)
0.036
0.712
-0.3 (-0.5;0.2)
0.5 (-0.2;1.7)
0.052
0.696
Yes (n = 8)
No (n = 29)
P value
Yes (n = 8)
No (n = 29)
P value
PNI
mean
0.3 (0.2;0.3)
0.1 (0.1;0.2)
0.042
0.737
0.3 (0.2;0.3)
0.1 (0.1;0.2)
0.046
0.733
10th percentile
0.1 (0.1;0.1)
0.0 (0.0;0.0)
0.011
0.797
0.1 (0.1;0.1)
0.0 (0.0;0.0)
0.013
0.789
20th percentile
0.1 (0.1;0.2)
0.1 (0.0;0.1)
0.022
0.767
0.2 (0.1;0.2)
0.1 (0.0;0.1)
0.035
0.746
30th percentile
0.2 (0.1;0.2)
0.1 (0.0;0.1)
0.024
0.763
0.2 (0.1;0.2)
0.1 (0.1;0.1)
0.039
0.741
40th percentile
0.2 (0.2;0.3)
0.1 (0.0;0.1)
0.027
0.759
0.2 (0.1;0.3)
0.1 (0.1;0.1)
0.042
0.737
50th percentile
0.3 (0.2;0.3)
0.1 (0.1;0.2)
0.029
0.754
0.3 (0.2;0.3)
0.1 (0.1;0.2)
0.035
0.746
60th percentile
0.3 (0.2;0.4)
0.2 (0.1;0.2)
0.032
0.750
0.3 (0.2;0.4)
0.1 (0.1;0.2)
0.035
0.746
70th percentile
0.4 (0.2;0.4)
0.2 (0.1;0.2)
0.035
0.746
0.4 (0.2;0.4)
0.2 (0.1;0.2)
0.039
0.741
80th percentile
0.4 (0.3;0.5)
0.2 (0.2;0.3)
0.046
0.733
0.4 (0.3;0.5)
0.2 (0.2;0.3)
0.042
0.746
skewness
0.4 (0.1;0.5)
0.8 (0.6;1.3)
0.022
0.767
0.3 (0.2;0.6)
0.8 (0.6;1.3)
0.020
0.772
kurtosis
-0.4 (-0.7;-0.1)
0.4 (-0.2;1.4)
0.018
0.776
-0.4 (-0.7;-0.1)
0.4 (-0.3;1.6)
0.035
0.746
mode
0.2 (0.1;0.4)
0.0 (0.0;0.1)
0.002
0.859
0.1 (0.1;0.3)
0.0 (0.0;0.1)
0.016
0.783
Yes (n = 13)
No (n = 16)
P value
Yes (n = 13)
No (n = 16)
P value
KRAS mutation
mean
0.5 (0.4;0.5)
0.3 (0.2;0.4)
0.009
0.788
0.5 (0.4;0.5)
0.3 (0.2;0.4)
0.010
0.784
SD
0.3 (0.3;0.5)
0.2 (0.1;0.3)
0.020
0.755
0.3 (0.3;0.5)
0.2 (0.1;0.4)
0.035
0.731
50th percentile
0.4 (0.2;0.5)
0.2 (0.2,0.3)
0.039
0.726
0.4 (0.2;0.5)
0.2 (0.2,0.3)
0.048
0.716
60th percentile
0.5 (0.3;0.6)
0.3 (0.2;0.4)
0.035
0.731
0.5 (0.4;0.5)
0.3 (0.2;0.4)
0.048
0.716
70th percentile
0.6 (0.4;0.7)
0.4 (0.3;0.5)
0.028
0.740
0.6 (0.4;0.7)
0.4 (0.3;0.5)
0.032
0.736
80th percentile
0.8 (0.5;0.9)
0.5 (0.3;0.6)
0.014
0.769
0.8 (0.5;0.9)
0.5 (0.3;0.6)
0.023
0.750
90h percentile
0.8 (0.8;1.4)
0.6 (0.4;0.9)
0.023
0.750
0.9 (0.8;1.3)
0.6 (0.4;0.9)
0.039
0.726
mode
1.3 (0.8;1.8)
0.6 (0.0;1.1)
0.007
0.793
1.3 (0.8;1.8)
0.6 (0.1;1.1)
0.007
0.793
mean
1.4 (1.2; 1.5)
0.9 (0.3;1.3)
0.018
0.760
1.3 (1.2; 1.5)
1.0 (0.3;1.3)
0.044
0.721
30th percentile
0.7 (0.5;0.8)
0.5 (0.2;0.7)
0.025
0.745
0.7 (0.6;0.8)
0.5 (0.2;0.6)
0.032
0.736
40th percentile
0.9 (0.8;1.1)
0.6 (0.2;0.8)
0.028
0.740
0.9 (0.8;1.1)
0.7 (0.2;0.8)
0.028
0.740
50th percentile
1.1 (0.9;1.4)
0.8 (0.2;1.0)
0.018
0.760
1.1 (1.0;1.2)
0.8 (0.2;1.0)
0.039
0.726
60th percentile
1.4 (1.1;1.6)
0.9 (0.3;1.2)
0.020
0.755
1.4 (1.2;1.5)
1.0 (0.3;1.3)
0.035
0.731
70th percentile
1.8 (1.4;1.8)
1.1 (0.3; 1.5)
0.028
0.740
1.7 (1.4;1.9)
1.2 (0.4;1.5)
0.032
0.736
80th percentile
2.1 (1.8;2.5)
1.4 (0.4;1.9)
0.016
0.764
2.1 (1.7;2.7)
1.5 (0.4;2.0)
0.032
0.736
90th percentile
2.7 (2.4;3.1)
1.9 (0.6;2.7)
0.025
0.745
2.7 (2.3;3.1)
1.9 (0.6;2.8)
0.048
0.716
kurtosis
0.5 (-0.6;1.9)
1.3 (0.9;5.1)
0.035
0.731
0.4 (-0.6;1.4)
2.0 (0.7;5.6)
0.018
0.760
Note. All figures of perfusion parameters in the above table have been rounded to one decimal place and are presented as median value (interquartile range) according to the data distribution. Numbers in bold are statistically significant P -values. Parameters in bold are high in area under the ROC curve. AUC, area under the concentration curve; PNI, perineural invasion; SD, standard deviation. with the Mann-Whitney U test. †Az= area under the ROC curve.
