Histogram Analysis of Perfusion Parameters from Dynamic Contrast-Enhanced MR Imaging with Tumor Characteristics and Therapeutic Response in Locally Advanced Rectal Cancer
Table 3
Correlation with treatment response of neoadjuvant chemoradiotherapy after rectal cancer.
Treatment Response
Parameter
Reader 1
Reader 2
TRG0,1,2(n=29)
TRG 3,4 (n=8)
P value
TRG0,1,2(n=29)
TRG3,4 (n=8)
P value
TRG
mean
0.4 (0.3;0.5)
0.4 (0.3;0.5)
0.685
0.4 (0.3;0.5)
0.4 (0.3;0.4)
0.854
maximum
1.3 (0.7;1.8)
0.9 (0.7;1.5)
0.685
1.3 (0.7;1.8)
0.9 (0.7;1.5)
0.605
skewness
0.9 (0.2;1.6)
0.8 (0.1;1.5)
0.912
0.8 (0.3;1.6)
0.8 (0.1;1.6)
0.912
kurtosis
0.4 (-0.9;2.1)
-0.1 (-1.2;1.9)
0.507
0.2 (-0.9;2.7)
-0.2 (-1.1;2.5)
0.825
mean
1.2 (0.8;1.4)
1.0 (0.9;1.1)
0.685
1.1 (0.7;1.3)
1.0(0.9;1.1)
0.483
maximum
3.3 (2.7;4.0)
3.5 (2.7;4.2)
1.000
3.5 (2.7;4.0)
3.5 (2.7;4.2)
0.971
skewness
1.3 (0.9;1.7)
1.3 (0.9;1.8)
0.971
1.3 (0.9;1.7)
1.4 (0.9;1.8)
0.941
kurtosis
1.1 (0.2;4.1)
2.1 (-0.1;3.9)
0.941
1.3 (0.3;3.6)
2.2 (-0.1;4.0)
0.941
CR (n=7)
nonCR (n=30)
P value
CR (n=7)
nonCR (n=30)
P value
CR
mean
0.3 (0.3;0.4)
0.4 (0.3;0.5)
0.461
0.4 (0.3;0.4)
0.4 (0.3;0.5)
0.587
maximum
1.0 (0.7;1.5)
1.2 (0.7;1.8)
0.816
1.0 (0.7;1.5)
1.2 (0.7;1.8)
0.727
skewness
1.0 (0.4;1.5)
0.8 (0.1; 1.6)
0.670
1.0 (0.4;1.6)
0.8 (0.1;1.6)
0.614
kurtosis
0.3 (-0.8;1.9)
0.3(-0.9;2.1)
0.907
0.1 (-0.8;2.5)
0.1(-0.9;2.7)
0.786
mean
1.0 (0.9;1.0)
1.2 (0.8;1.4)
0.332
0.9 (0.9;1.0)
1.2 (0.7;1.4)
0.201
maximum
3.8 (2.9; 4.2)
3.3 (2.7;4.0)
0.756
3.8 (2.9;4.2)
3.4 (2.7;4.0)
0.786
skewness
1.5 (1.1;1.8)
1.3 (0.7;1.7)
0.510
1.6 (1.2;1.8)
1.3 (0.8;1.7)
0.438
kurtosis
3.1 (0.8;3.9)
1.1(-0.5;4.1)
0.535
3.1 (0.9;4.0)
1.3(-0.5;3.6)
0.535
Note. TRG, tumor regression grade; TRG0, no regression; TRG1, dominant tumor mass with obvious fibrosis and/or vasculopathy; TRG2, dominantly fibrotic changes with few tumor cells or groups; TRG3, very few tumor cells in fibrotic tissue with or without mucous substance; TRG4, no tumor cells, only fibrotic mass; TRG nonresponders (Grades 0,1, and 2) and TRG responders (Grades 3 and 4); CR, complete response. All figures of perfusion parameters in the above table have been rounded to one decimal place and are presented as median value (interquartile range) according to the data distribution. with the Mann-Whitney U test.
