The Potential of Fluocinolone Acetonide to Mitigate Inflammation and Lipid Accumulation in 2D and 3D Foam Cell Cultures

Figure 3

Effects of FA and Dex on foam cell proliferation and lipid accumulation. Quantification of double-stranded DNA (dsDNA) and normalized cholesteryl ester accumulation in THP-1 derived foam cells cultured in media containing 10% fetal bovine serum and 100 μg/mL oxidized low-density lipoproteins and treated with different concentrations of Fluocinolone acetonide (FA) and dexamethasone (Dex). (a) dsDNA quantification results obtained from Picogreen assay. (b) Cholesteryl ester accumulation results normalized to the corresponding dsDNA amounts. p < 0.05 between the indicated groups and untreated controls. p < 0.05 between FA and Dex at the same concentration. Data presented were representative of 3 independent experiments, n = 3.

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