The Potential of Fluocinolone Acetonide to Mitigate Inflammation and Lipid Accumulation in 2D and 3D Foam Cell Cultures

Figure 4

Evaluation of cytokine release from foam cells treated with FA/Dex. (a) Chemiluminescent images of cytokine array results from THP-1 derived foam cells cultured in media containing 10% fetal bovine serum and 100 μg/mL oxidized low-density lipoproteins and treated with 1 μg/mL Fluocinolone acetonide (FA)/ dexamethasone (Dex). Cytokines related to inflammation and lipid accumulation that registered differences in secreted levels are labelled in the top panel; (b) and (c) quantification of the cytokine secretions. Cytokines are categorized into two categories: (b) inflammation, and (c) lipid accumulation. p < 0.05 between the indicated groups and untreated controls. p < 0.05 between FA and Dex-treated groups. Data presented were representative of 3 independent experiments, n = 3.

(a) Chemiluminescent images

(b) Inflammation

(c) Lipid accumulation