Twist Expression in Circulating Hepatocellular Carcinoma Cells Predicts Metastasis and Prognoses
Table 1
Information and clinical characteristics of the 80 HCC patients.
Clinical variables
Number (%)
Number of samples containing CTCs (%)
Number of samples containing Twist+ CTCs (%)
CTCs numbers
Twist+ CTCs numbers
Range
Average
Range
Average
Age (years)
<30
19 (23.70%)
7 (36.84%)
6 (31.58%)
0~49
13.93
0~12
3.65
30-50
39 (48.80%)
34 (87.18%)
29 (74.36%)
2~52
14.37
0~16
3.87
>50
22 (27.50%)
21 (95.45%)
19 (86.37%)
1~50
14.07
0~13
3.19
Gender
Males
70 (87.50%)
55 (78.57%)
48 (68.57%)
0~52
14.41
0~16
4.05
Females
10 (12.50%)
7 (70.00%)
6 (60.00%)
0~49
14.04
0~14
3.55
Child-Pugh class
A
62 (77.50%)
44 (70.97%)
36 (58.06%)
0~48
14.04
0~12
2.96
B
12 (15.00%)
12 (100.00%)
12 (100.00%)
1~35
14.71
0~13
3.57
C
6 (7.50%)
6 (100.00%)
6 (100.00%)
4~52
15.22
1~16
4.68
Cirrhosis
With
57 (71.25%)
52 (91.23%)
51 (89.47%)
0~52
14.84
0~16
3.46
Without
23 (28.75%)
10 (43.48%)
3 (13.04%)
0~50
14.17
0~13
3.19
Tumor number
Single
31 (38.75%)
14 (45.16%)
6 (19.35%)
0~38
12.88
0~12
2.55
Multiple
49 (61.25%)
48 (97.96%)
48 (97.96%)
1~52
17.05
0~16
4.27
Tumor size(cm)
<3
16 (20.00%)
5 (31.25%)
2 (12.50%)
0~24
13.02
0~11
2.84
3-5
19 (23.80%)
15 (78.95%)
12 (63.16%)
0~44
17.47
0~16
3.41
>5
45 (56.20%)
42 (93.30%)
40 (88.89%)
2~52
20.05
1~16
4.51
AFP (ng/ml)
<20
17 (21.25%)
6 (35.29%)
3 (17.65%)
0~50
14.15
0~12
3.97
20-100
19 (23.75%)
13 (68.42%)
9 (47.37%)
0~51
15
0~13
3.47
100-500
14 (17.50%)
14 (100.00%)
14 (100.00%)
0~50
14.53
0~16
3.41
>500
30 (37.50%)
29 (96.67%)
28 (93.33%)
0~52
15.13
0~14
3.59
Portal vein tumor thrombus
With
46 (57.50%)
46 (100.00%)
46 (100.00%)
3~52
25.57
1~16
5.26
Without
34 (42.50%)
16 (47.06%)
8 (23.53%)
0~37
14.42
0~12
2.14
TNM staging
Stage I
9 (11.25%)
2 (22.22%)
0 (00.00%)
0~33
13.62
0~11
2.02
Stage II
25 (31.25%)
17 (68.00%)
13 (52.00%)
0~36
16.03
0~13
2.44
Stage III
36 (45.00%)
33 (91.67%)
31 (86.11%)
0~50
21.47
1~16
4.64
Stage IV
10 (12.50%)
10 (100.00%)
10 (100.00%)
2~52
25.17
1~16
5.82
Note. American Joint Committee on Cancer TNM Staging for Liver Tumors (7th edition, 2010, ISBN 0387884408). AFP: alpha-fetoprotein; HCC: hepatocellular carcinoma; CTCs: circulating tumor cells.
